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Literature summary for 3.4.21.89 extracted from

  • Bonnemain, C.; Raynaud, C.; Reglier-Poupet, H.; Duball, I.; Frehel, C.; Lety, M.A.; Berche, P.; Charbit, A.
    Differential roles of multiple signal peptidases in the virulence of Listeria monocytogenes (2004), Mol. Microbiol., 51, 1251-1266.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Listeria monocytogenes Inactivation of sipX does not effect intracellular multiplication of Listeria monocytogenes but significantly reduces bacterial virulence (about 100fold). Inactivation of sipZ impairs the secretion of phospholipase C and listeriolysin O, restricts intracellular multiplication and almost abolishes virulence. Inactivation of sipY has no detectable effects ?
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Organism

Organism UniProt Comment Textmining
Listeria monocytogenes
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 three SPase I genes in the genome of Listeria monocytogenes encode the proteins SipX, SipY, and SipZ
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Inactivation of sipX does not effect intracellular multiplication of Listeria monocytogenes but significantly reduces bacterial virulence (about 100fold). Inactivation of sipZ impairs the secretion of phospholipase C and listeriolysin O, restricts intracellular multiplication and almost abolishes virulence. Inactivation of sipY has no detectable effects Listeria monocytogenes ?
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Synonyms

Synonyms Comment Organism
SipX
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 Listeria monocytogenes
SipY
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 Listeria monocytogenes
SipZ
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 Listeria monocytogenes
Spase I
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 Listeria monocytogenes