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Literature summary for 3.4.21.89 extracted from

  • Paetzel, M.; Dalbey, R.E.; Strynadka, N.C.J.
    Crystal structures of a bacterial signal peptidase in complex with a beta-lactam inhibitor (1998), Nature, 396, 186-190.
    View publication on PubMed
Search for more literature for 3.4.21.89

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant delta2-75 in complex with beta-lactam inhibitor (5S,6S) penem, crystals belong to orthorhombic space group P2(1)2(1)2 with unit cell dimensions a : 110.7 A, b : 113.2 A, c : 99.2 A, crystal structure of apoenzyme in absence of substrate or inhibitor solved by molecular replacement, space group P4(1)2(1)2, unit cell dimensions a : b : 112.4 A, c : 198.7 A Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(5S,6S) penem beta-lactam inhibitor Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Escherichia coli 16020
-
plasma membrane membrane-bound, carboxyterminal catalytic region which resides in the periplasmic space Escherichia coli 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27950
-
 deduced from amino acid sequence Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
signal peptides from preproteins + H2O Escherichia coli
-
 mature proteins
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
signal peptides from preproteins + H2O
-
 Escherichia coli mature proteins
-
 ?

Synonyms

Synonyms Comment Organism
SPase
-
 Escherichia coli
type I signal (leader) peptidase
-
 Escherichia coli