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Literature summary for 3.4.21.84 extracted from

  • Abate, W.; Sattar, A.A.; Liu, J.; Conway, M.E.; Jackson, S.K.
    Evaluation of recombinant factor C assay for the detection of divergent lipopolysaccharide structural species and comparison with Limulus amebocyte lysate-based assays and a human monocyte activity assay (2017), J. Med. Microbiol., 66, 888-897 .
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide factor C activation through lipopolysaccharide assay. Detection of various LPS structural species by rFC-based assay. Several bacterial species are used as sources for endotoxin/lipopolysaccharide, overview. Highest activity is obtained with Escherichia coli LPS O111:B4 and J5, lowest activity with LPS from Francisella tularensis or Salmonella lipid A. Induction of interleukin IL-6 by various LPS structural species Limulus polyphemus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-factor B + H2O Limulus polyphemus activation factor B + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Limulus polyphemus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amoebocyte
-
 Limulus polyphemus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-factor B + H2O activation Limulus polyphemus factor B + ?
-
 ?

Synonyms

Synonyms Comment Organism
Factor C
-
 Limulus polyphemus

General Information

General Information Comment Organism
metabolism the enzyme is part of the clotting cascade of Limulus polyphemus. Factor C, the first component of the cascade, is a serine protease that is activated by endotoxin binding. The cascade, initiated by lipopolysaccharide, culminates in the activation of the pro-clotting enzyme to its active form, the clotting enzyme, which in turn acts on coagulogen to convert it into the coagulin clot Limulus polyphemus
physiological function Factor C activates factor B in the clotting cascade in Limulus polyphemus Limulus polyphemus