Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P10144 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
natural killer cell | - |
Homo sapiens | - |
T-lymphocyte | cytotoxic T lymphocytes | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation, correlated with unfavorable inflammatory profile, as described by elevated levels of validated adipokines such as interleukin-6, TNF-alpha, and WISP1. Multivariate linear regression analysis shows that increased GrB is associated with type 2 diabetes diagnosis independently from possible confounders | Homo sapiens |
physiological function | granzyme B (GrB) is a serine protease produced by some leukocytes, including cytotoxic lymphocytes and macrophages, that exerts both intracellular apoptotic function and extracellular functions, leading to tissue injury, inflammation and repair. Role for GrB in the pathogenesis of several chronic inflammatory diseases | Homo sapiens |