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Literature summary for 3.4.21.79 extracted from
- Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein (2015), Antimicrob. Agents Chemother., 59, 669-672 .
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein. Therapeutic efficacies of recombinant antibody-mediated antimalarial immunotherapeutics based on granzyme B, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | creation and synthesis of an antimalarial fusion protein consisting of granzyme B fused to a merozoite surface protein 4 (MSP4)-specific single-chain Fv protein (scFv), which targets the enzyme to infected erythrocytes, with up to an 8fold reduction in the IC50 of 176 nM compared to wild-type granzyme B against schizont-stage Plasmodium falciparum strain 3D7A, method, overview. Generation of a single-chain variable fragment (scFv) from an MSP4EGF-like domain-specific murine antibody, 2.44IgG1 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P10144 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | granzyme B acts against schizont-stage Plasmodium falciparum with IC50 of 0.00159 mM | Homo sapiens |
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Release 2023.1 (January 2023)
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