Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-glycan + H2O | Homo sapiens | - |
? | - |
? | |
biglycan + H2O | Homo sapiens | - |
? | - |
? | |
decorin + H2O | Homo sapiens | - |
? | - |
? | |
fibrillin-1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P10144 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-glycan + H2O | - |
Homo sapiens | ? | - |
? | |
beta-glycan + H2O | 100 kDa protein, cleavage by the enzyme into fragments of about 60 kDa and 40 kDa | Homo sapiens | ? | - |
? | |
biglycan + H2O | - |
Homo sapiens | ? | - |
? | |
biglycan + H2O | 40 kDa protein, cleavage by the enzyme into fragments of about 30 kDa and 20 kDa | Homo sapiens | ? | - |
? | |
decorin + H2O | - |
Homo sapiens | ? | - |
? | |
decorin + H2O | 65 kDa protein, cleavage by the enzyme into fragments of about 50 kDa and 30 kDa | Homo sapiens | ? | - |
? | |
fibrillin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme cleaves exracellular matrix proteins, release of active TGF-beta1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |
pro-apoptotic serine protease | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | extracellular levels of the enzyme are elevated in the bodily fluids in chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis | up |
General Information | Comment | Organism |
---|---|---|
physiological function | pathogenic extracellular role for GrB in cardiovascular disease, during inflammation, the enzyme accumulates in the extracellular space, retains its activity, and is capable of cleaving extracellular matrix proteins | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
decorin | pH 7.4, 37°C | Homo sapiens | |
1.7 | - |
biglycan | pH 7.4, 37°C | Homo sapiens | |
5.9 | - |
beta-glycan | pH 7.4, 37°C | Homo sapiens |