Literature summary for 3.4.21.79 extracted from

Bhela, S.; Kempsell, C.; Manohar, M.; Dominguez-Villar, M.; Griffin, R.; Bhatt, P.; Kivisakk-Webb, P.; Fuhlbrigge, R.; Kupper, T.; Weiner, H.; Baecher-Allan, C.
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo tregs in multiple sclerosis and in response to IL-6 (2015), J. Immunol., 194, 2180-2189.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
extracellular	extracellular fluids	Homo sapiens	-	-
intracellular	-	Homo sapiens	5622	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P10144	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-lymphocyte	cytotoxic, interleukin-6 induces CD4 T cells to express the enzyme	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	interleukin-6 induces CD4 T cells to express the enzyme	up

General Information

General Information	Comment	Organism
malfunction	Tresp cells from patients with multiple sclerosis resist Treg suppression via a mechanism that involves GzmB	Homo sapiens
physiological function	in contrast to the intracellular GzmB that mediates apoptosis, GzmB can be found in extracellular fluids where it is hypothesized to regulate other cellular processes. GzmB-induced apoptosis involves the granule-mediated delivery of GzmB into the cytoplasm of target cells. Extracellular enzyme strongly inhibits Treg suppression, without altering Treg viability, nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell suppression by HLA-DR-CD25hiCD127lo tregs in multiple sclerosis and in response to interleukin-6. The suppression-abrogating cytokine interleukin-6 augments GzmB expression by human CD4 T cells, and it inhibits Treg suppression via this nonapoptotic GzmB-mediated mechanism. DR2CD127lo Tregs stimulated in the presence of extracellular GzmB exhibit reduced expression of the suppression-associated molecules CD39 and PD-L1	Homo sapiens

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Release 2023.1 (January 2023)