Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P04187 | gene gzmB | - |
Mus musculus B6 | P04187 | gene gzmB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | cytotoxic T cell | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
metabolism | gzmB+ cytotoxic T cell-mediated apoptosis (via phosphatidylserine translocation, mitochondrial depolarization, cytochrome c release, and caspase-3 activation) is severely reduced in 3T9 cells lacking either Bim or both Bak and Bax, gzmB+ cytotoxic T cell-mediated apoptosis is not affected in SV40-transformed mouse embryonic fibroblast cells lacking Bak/Bax.Role of Bim in gzmB-mediated apoptosis, overview | Mus musculus |
physiological function | cytotoxic T cells use perforin and granzyme B to kill virus-infected cells and cancer cells. Granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion in cytotoxic T lymphocytes | Mus musculus |