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Literature summary for 3.4.21.79 extracted from

  • Catalan, E.; Jaime-Sanchez, P.; Aguilo, N.; Simon, M.M.; Froelich, C.J.; Pardo, J.
    Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim dependent fashion (2015), J. Biol. Chem., 290, 6868-6877.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus P04187 gene gzmB
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Mus musculus B6 P04187 gene gzmB
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte cytotoxic T cell Mus musculus
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General Information

General Information Comment Organism
metabolism gzmB+ cytotoxic T cell-mediated apoptosis (via phosphatidylserine translocation, mitochondrial depolarization, cytochrome c release, and caspase-3 activation) is severely reduced in 3T9 cells lacking either Bim or both Bak and Bax, gzmB+ cytotoxic T cell-mediated apoptosis is not affected in SV40-transformed mouse embryonic fibroblast cells lacking Bak/Bax.Role of Bim in gzmB-mediated apoptosis, overview Mus musculus
physiological function cytotoxic T cells use perforin and granzyme B to kill virus-infected cells and cancer cells. Granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion in cytotoxic T lymphocytes Mus musculus