Application | Comment | Organism |
---|---|---|
medicine | the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P04187 | gene gzmB | - |
Mus musculus B6 | P04187 | gene gzmB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
natural killer cell | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
malfunction | the mouse pathogen Brucella microti persists in mice lacking perforin or granzyme B as well as in mice depleted of Tc cells | Mus musculus |
physiological function | the enzyme is required for elimination of the mouse pathogen Brucella microti from liver and spleen and is necessary to inhibit Brucella microti replication in primary macrophages | Mus musculus |