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Literature summary for 3.4.21.79 extracted from

  • Boivin, W.A.; Cooper, D.M.; Hiebert, P.R.; Granville, D.J.
    Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma (2009), Lab. Invest., 89, 1195-1220.
    View publication on PubMed
Search for more literature for 3.4.21.79

Inhibitors

Inhibitors Comment Organism Structure
protease inhibitor-9 endogenous human inhibitor Homo sapiens
serpina3n inhibitor for human and mouse GrB, expressed by Sertoli cells. Inhibitor shares homology with human alpha-1-anti-chymotrypsin Homo sapiens
serpina3n inhibitor for human and mouse GrB, expressed by Sertoli cells. Inhibitor shares homology with human alpha-1-anti-chymotrypsin Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell type II Homo sapiens
-
basophil
-
 Homo sapiens
-
bronchoalveolar lavage expressed in the bronchoalveolar lavage of patients with chronic obstructive pulmonary disease and lung inflammation Homo sapiens
-
cerebrospinal fluid expressed in the cerebrospinal fluid of multiple sclerosis and Rasmussen encephalitis patients Homo sapiens
-
chondrocyte
-
 Homo sapiens
-
dendritic cell
-
 Homo sapiens
-
granulosa cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
macrophage activated macrophages Homo sapiens
-
mast cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-
plasma
-
 Homo sapiens
-
Sertoli cell
-
 Homo sapiens
-
smooth muscle cell
-
 Homo sapiens
-
spermatocyte
-
 Homo sapiens
-
syncytiotrophoblast
-
 Homo sapiens
-
synovial cell expressed in the synovial fluid of rheumatoid arthritis patients Homo sapiens
-
T-lymphocyte CD4+ cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine receptor + H2O extracellular GrB substrate. Implication: cleavage results in a reduction of the receptor in neuromuscular junctions and yields an autoantigenic fragment Homo sapiens ?
-
 ?
aggrecan + H2O extracellular GrB substrate. Implication: Disruption of structural integrity in cartilage Homo sapiens ?
-
 ?
cartilage proteoglycans + H2O extracellular GrB substrate. Implication: Disruption of structural integrity in cartilage Homo sapiens ?
-
 ?
FGFR1 + H2O extracellular GrB substrate. Implication: cleavage activates pro-cell death functions as well as inactivates pro-growth signals Homo sapiens ?
-
 ?
Fibrinogen + H2O extracellular GrB substrate. Implication: matrix form of fibrinogen is cleaved. The uncleaved protein is responsible for platelet adhesion and thrombus growth. Cleavage results in anti-thrombosis implications Homo sapiens ?
-
 ?
Fibronectin + H2O extracellular GrB substrate. Implication: cell adhesion, migration, and anoikis Homo sapiens ?
-
 ?
Laminin + H2O extracellular GrB substrate. Implication: cell adhesion, anoikis Homo sapiens ?
-
 ?
neuronal glutamate receptor + H2O extracellular GrB substrate. Implication: GrB cleaves the non-glycosylated form of the receptor into an autoantigenic fragment Homo sapiens ?
-
 ?
Notch1 + H2O extracellular GrB substrate. Implication: cleavage results in cell signaling affecting tumor survival and antiviral activities Homo sapiens ?
-
 ?
plasmin + H2O extracellular GrB substrate. Implication: as plasmin is pro-angiogenic, cleavage results in the reduction of angiogenesis Homo sapiens ?
-
 ?
plasminogen + H2O extracellular GrB substrate. Implication: cleavage yields angiostatin, which is anti-angiogenic. Implications in angiogenesis Homo sapiens ?
-
 ?
smooth muscle cell matrix + H2O extracellular GrB substrate. Implication: cell adhesion, anoikis Homo sapiens ?
-
 ?
Vitronectin + H2O extracellular GrB substrate. Implication: GrB cleavage site in integrin-binding domain, implications in cell adhesion, migration, and anoikis Homo sapiens ?
-
 ?
von Willebrand factor + H2O extracellular GrB substrate. Implication: GrB cleavage site in the domain of platelet interaction, prevention/delay of thrombosis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
granzyme B
-
 Mus musculus
granzyme B
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens serum levels of GrB are elevated in several diseases such as human immunodeficiency virus-1 infection, Epstein-Barr virus infection, arthritis and others up

General Information

General Information Comment Organism
physiological function GrB plays an important role in inflammatory diseases and cancer. Infiltrating immune cells during chronic inflammation results in elevated levels of GrB to diseased tissue and induces apoptosis in damaged and inflamed areas. Extracellular concentrations of GrB in bodily fluids are elevated in various diseases Homo sapiens