Literature summary for 3.4.21.79 extracted from

Cai, S.F.; Fehniger, T.A.; Cao, X.; Mayer, J.C.; Brune, J.D.; French, A.R.; Ley, T.J.
Differential expression of granzyme B and C in murine cytotoxic lymphocytes (2009), J. Immunol., 182, 6287-6297.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	wild-type CD8alpha+ intraepithelial lymphocytes constitutively express granzyme B	Mus musculus	-
T-lymphocyte	granzyme B and granzyme C expression is detected in CD4+ and CD8+ T cells activated with CD3/CD28 beads or MLRs	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
granzyme B	-	Mus musculus
GzmB	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	stimulation of NK cells in vitro with IL-15 induce expression of granzyme C	up

General Information

General Information	Comment	Organism
malfunction	knockout GzmB-/- mice which have a small deletion in the granzyme B gene express granzyme C earlier and more abundantly in lymphocytes on a per-cell basis compared to wild-type, suggesting that the deleted 350-bp region in the granzyme B gene is important for the regulation of both granzymes B and granzyme C. Intraepithelial lymphocytes in GzmB-/- knockout mice likewise express granzyme C	Mus musculus

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Release 2023.1 (January 2023)