Cloned (Comment) | Organism |
---|---|
recombinantly expressed | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasmacytoid dendritic cell | elevated expression of granzyme B | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
granzyme B | - |
Homo sapiens |
GrB | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | GrB expression in plasmacytoid dendritic cells is strictly regulated on a transcriptional level involving Janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), and STAT5. Interleukin-3 (IL-3), secreted by activated T cells, plays a central role for GrB induction | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell proliferation in a GrB-dependent, perforin-independent manner | Homo sapiens |