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Literature summary for 3.4.21.79 extracted from

  • Jahrsdoerfer, B.; Vollmer, A.; Blackwell, S.E.; Maier, J.; Sontheimer, K.; Beyer, T.; Mandel, B.; Lunov, O.; Tron, K.; Nienhaus, G.U.; Simmet, T.; Debatin, K.M.; Weiner, G.J.; Fabricius, D.
    Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion (2010), Blood, 115, 1156-1165.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinantly expressed Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasmacytoid dendritic cell elevated expression of granzyme B Homo sapiens
-

Synonyms

Synonyms Comment Organism
granzyme B
-
Homo sapiens
GrB
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens GrB expression in plasmacytoid dendritic cells is strictly regulated on a transcriptional level involving Janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), and STAT5. Interleukin-3 (IL-3), secreted by activated T cells, plays a central role for GrB induction up

General Information

General Information Comment Organism
physiological function Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell proliferation in a GrB-dependent, perforin-independent manner Homo sapiens