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Literature summary for 3.4.21.79 extracted from

  • Casciola-Rosen, L.; Miagkov, A.; Nagaraju, K.; Askin, F.; Jacobson, L.; Rosen, A.; Drachman, D.B.
    Granzyme B: evidence for a role in the origin of myasthenia gravis (2008), J. Neuroimmunol., 201-202, 33-40.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.79

Application

Application Comment Organism
medicine potential role for granzyme B in the process of initiation of myasthenia gravis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in thymus glands from myasthenia patients Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 immunoblotting Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information absent in K562 cells Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-
thymus granzyme B is present in thymus glands from myasthenia patients, but is absent in thymus from normal adult subjects Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine receptor granzyme B efficiently and specifically cleaves alpha and epsilon subunits of acetylcholine receptor, especially the epsilon subunit Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GrB
-
 Homo sapiens