Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | sepsis induces platelet granzyme B expression. In septic mice, granzyme B expression significantly increases by 24 h in megakaryocytes and platelets | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | platelets are lymphotoxic effectors in sepsis via granzyme B | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | granzyme B mRNA expression is increased 2.9fold in a severe septic human subject | Homo sapiens | - |
blood platelet | septic megakaryocytes produce platelets with acutely altered mRNA profiles, and these platelets mediate lymphotoxicity via granzyme B | Mus musculus | - |
megakaryocyte | septic megakaryocytes produce platelets with acutely altered mRNA profiles, and these platelets mediate lymphotoxicity via granzyme B | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | platelets from septic granzyme B null (-/-) mice show no lymphotoxicity | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytotoxic serine protease granzyme B | - |
Mus musculus |
cytotoxic serine protease granzyme B | - |
Homo sapiens |