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Literature summary for 3.4.21.79 extracted from

  • Freishtat, R.J.; Natale, J.; Benton, A.S.; Cohen, J.; Sharron, M.; Wiles, A.A.; Ngor, W.M.; Mojgani, B.; Bradbury, M.; Degnan, A.; Sachdeva, R.; Debiase, L.M.; Ghimbovschi, S.; Chow, M.; Bunag, C.; Kristosturyan, E.; Hoffman, E.P.
    Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity (2009), Am. J. Respir. Crit. Care Med., 179, 467-473.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information sepsis induces platelet granzyme B expression. In septic mice, granzyme B expression significantly increases by 24 h in megakaryocytes and platelets Mus musculus

Application

Application Comment Organism
medicine platelets are lymphotoxic effectors in sepsis via granzyme B Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet granzyme B mRNA expression is increased 2.9fold in a severe septic human subject Homo sapiens
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blood platelet septic megakaryocytes produce platelets with acutely altered mRNA profiles, and these platelets mediate lymphotoxicity via granzyme B Mus musculus
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megakaryocyte septic megakaryocytes produce platelets with acutely altered mRNA profiles, and these platelets mediate lymphotoxicity via granzyme B Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information platelets from septic granzyme B null (-/-) mice show no lymphotoxicity Mus musculus ?
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Synonyms

Synonyms Comment Organism
cytotoxic serine protease granzyme B
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Mus musculus
cytotoxic serine protease granzyme B
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Homo sapiens