Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | natural killer cells stimulated in vitro with interleukin-2 express progressively greater amounts of perforin and granzyme B | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | granzyme H participates in the anti-adenovirus response by both inhibiting virus replication directly and simultaneously re-sensitizing infected cell to granzyme B-induced cell death | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice deficient in granzyme B are up to 100000fold more sensitive to the natural mouse proxivirus pathogen ectromelia than are wild-type mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L4-100k assembly protein | acts as a sink that binds to and inhibits granzyme B, preventing target cell death | Homo sapiens | |
additional information | natural killer cells stimulated in vitro with interleukin-2 reduce their granzyme H levels over 3-4 days | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
granzyme H | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cytotoxic T-lymphocyte cell line | - |
Homo sapiens | - |
natural killer cell | express high levels of granzyme H but relatively low levels of granzyme B | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA binding protein + H2O | granzyme B and granzyme H (cleavage at Met118 and Phe121) | Homo sapiens | ? | - |
? | |
L4-100k assembly protein + H2O | granzyme H | Homo sapiens | ? | - |
? | |
additional information | granzyme H does not cleave BID or inhibitor of caspase-activated death, does not activate caspases | Homo sapiens | ? | - |
? | |
pro-caspase-3 + H2O | granzyme B | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Granzyme H | - |
Homo sapiens |