Application | Comment | Organism |
---|---|---|
additional information | cytotoxic granule-mediated death of both primary and transformed beta cells requires granzyme B. Early cell death is completely dependent on granzyme B. Death induced by granzyme B is dependent on cosecretion with perforin | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | granzyme B deficient mice lack expression of linked granzyme-loci, due to accidental effects of the thymidine kinase enhancer integrated into the granzyme locus on mouse Chromosome 14 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | to protect beta cells from allogeneic CTL attack, one needs to inhibit the perforin/granzyme and probably also the TNFalpha pathway. Granzyme B-dependent death of NIT-1 cells is not inhibited by Bcl-2 overexpression | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
NOD/Lt, NOD/lpr, NOD.TNFR-/- and C57BL/mice, or strain 129(H-2b) backcrossed onto BL/6 for a minimum of 10 generations | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cytotoxic T-lymphocyte cell line | - |
Mus musculus | - |