Application | Comment | Organism |
---|---|---|
medicine | A streptolysin-O/GrB combination results in the induction of p53 accumulation and transcriptional activity associated with strong induction of apoptotic cell death in T1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment of T1 cells with pifithrin-alpha results in inhibition of p53 phosphorylation and in a significant decrease in GrB-induced apoptotic T1 cell death. siRNA targeting p53 induces inhibition of streptolysin-O/GrB-mediated apoptotic T1 cell death | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
BID + H2O | - |
Homo sapiens | truncated BID + ? | - |
? | |
p35 + H2O | GrB-induces phosphorylation of p53 | Homo sapiens | ? | - |
? | |
pro-caspase-3 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |