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Literature summary for 3.4.21.79 extracted from

  • Meslin, F.; Thiery, J.; Richon, C.; Jalil, A.; Chouaib, S.
    Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells (2007), J. Biol. Chem., 282, 32991-32999.
    View publication on PubMed

Application

Application Comment Organism
medicine A streptolysin-O/GrB combination results in the induction of p53 accumulation and transcriptional activity associated with strong induction of apoptotic cell death in T1 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information treatment of T1 cells with pifithrin-alpha results in inhibition of p53 phosphorylation and in a significant decrease in GrB-induced apoptotic T1 cell death. siRNA targeting p53 induces inhibition of streptolysin-O/GrB-mediated apoptotic T1 cell death Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BID + H2O
-
Homo sapiens truncated BID + ?
-
?
p35 + H2O GrB-induces phosphorylation of p53 Homo sapiens ?
-
?
pro-caspase-3 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
GrB
-
Homo sapiens