Literature summary for 3.4.21.79 extracted from

Nowacki, T.M.; Kuerten, S.; Zhang, W.; Shive, C.L.; Kreher, C.R.; Boehm, B.O.; Lehmann, P.V.; Tary-Lehmann, M.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells (2007), Cell. Immunol., 247, 36-48.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	GzB is not induced in purified CD8+ cells by CEF peptides ex vivo. Low frequencies of GzB producing CD8+ cells after mitogen stimulation. IFN-gamma positive, GzB negative CD8+ memory cells convert into GzB producing cells within 2 days after antigen stimulation. Induction of GzB producing CD8+ cells after Vaccinia virus booster immunization. HIV peptides induce GzB production in HIV-infected individuals directly ex vivo	Homo sapiens

Application

Application	Comment	Organism
medicine	ELISPOT measurements of granzyme B permit the identification of actively ongoing CD8+ cell responses. Importance for immune diagnostic of infections, transplantation, allergies, autoimmune diseases, tumors and vaccine development	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	CD8+ T cell	Homo sapiens	-
peripheral blood mononuclear cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GzB	-	Homo sapiens

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Release 2023.1 (January 2023)