Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | secreted after Fcepsilon-receptor-mediated activation in cytoplasmic granules of bone marrow-derived mast cells | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | activated mast cells contribute, via secreted gzmB, to cell death, increased vascular permeability, leukocyte extravasation and subsequent inflammatory processes in affected tissues. GzmB-induced detachment of adherent mouse embryonic fibroblasts leads to anoikis. GzmB induces a disorganization of endothelial cell-cell contacts | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gzmB-deficient mice do not cause cell death in susceptible adherent target cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | is associated with cytoplasmic granules of bone marrow-derived mast cells | Mus musculus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
Western blot analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells express GzmB | Mus musculus | - |
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Ile-Glu-Pro-Asp-p-nitroanilide + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GzmB | - |
Mus musculus |