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Literature summary for 3.4.21.79 extracted from

  • Sun, J.; Whisstock, J.C.; Harriott, P.; Walker, B.; Novak, A.; Thompson, P.E.; Smith, A.I.; Bird, P.I.
    Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop (2001), J. Biol. Chem., 276, 15177-15184.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A339G site-directed mutagenesis Homo sapiens
C335A site-directed mutagenesis Homo sapiens
C341A site-directed mutagenesis Homo sapiens
C341S site-directed mutagenesis Homo sapiens
E340A site-directed mutagenesis Homo sapiens
E340D site-directed mutagenesis Homo sapiens
E344A site-directed mutagenesis Homo sapiens
E344D site-directed mutagenesis Homo sapiens
F336A site-directed mutagenesis Homo sapiens
M343A site-directed mutagenesis Homo sapiens
S334A site-directed mutagenesis Homo sapiens
S345A site-directed mutagenesis Homo sapiens
T327R site-directed mutagenesis Homo sapiens
V337A site-directed mutagenesis Homo sapiens
V338A site-directed mutagenesis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
serpin proteinase inhibitor 9
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0058
-
2-aminobenzoyl-IEPDSSMESK-dnp pH 7.4, 37°C Homo sapiens
0.0058
-
2-aminobenzoyl-IEPDSSMEK-dnp pH 7.4, 37°C, wild-type Homo sapiens
0.0068
-
2-aminobenzoyl-IEPDSSMEK-dnp pH 7.4, 37°C, mutant K24A Homo sapiens
0.013
-
2-aminobenzoyl-VVADSSMESK-dnp pH 7.4, 37°C Homo sapiens
0.0387
-
2-aminobenzoyl-IEPDSSMEK-dnp pH 7.4, 37°C, mutant K27A Homo sapiens
0.0643
-
2-aminobenzoyl-VVAESSMESK-dnp pH 7.4, 37°C Homo sapiens
0.0701
-
2-aminobenzoyl-VVADSSMASK-dnp pH 7.4, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-PKcs + H2O Homo sapiens
-
?
-
?
fibrillarin + H2O Homo sapiens
-
?
-
?
La/SS-B + H2O Homo sapiens
-
?
-
?
Mi-2 + H2O Homo sapiens
-
?
-
?
additional information Homo sapiens induces apoptosis of abnormal cells by cleaving intracellular proteins ?
-
?
NuMA + H2O Homo sapiens
-
?
-
?
PARP + H2O Homo sapiens
-
?
-
?
PMS-1 + H2O Homo sapiens
-
?
-
?
PMS-2 + H2O Homo sapiens
-
?
-
?
pro-caspase-10 + H2O Homo sapiens
-
?
-
?
pro-mCASP-3 + H2O Homo sapiens
-
caspase-3 + ?
-
?
pro-mCASP-7 + H2O Homo sapiens
-
caspase-7 + ?
-
?
topoisomerase-1 + H2O Homo sapiens
-
?
-
?
U1-70kD + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-IEPDSSMEK-dnp + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-IEPDSSMESK-dnp + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-Val-Val-Ala-Asp-Ser-Ser-Met-Glu-Lys-dnp + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-Val-Val-Ala-Glu-Ser-Ser-Met-Glu-Lys-dnp + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-VVADSSMASK-dnp + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-VVADSSMESK-dnp + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-VVAESSMESK-dnp + H2O
-
Homo sapiens ?
-
?
DNA-PKcs + H2O
-
Homo sapiens ?
-
?
DNA-PKcs + H2O directly and efficiently cleaved in vitro and in vivo, abolishes kinase activity Homo sapiens ?
-
?
fibrillarin + H2O
-
Homo sapiens ?
-
?
La/SS-B + H2O
-
Homo sapiens ?
-
?
Mi-2 + H2O
-
Homo sapiens ?
-
?
additional information induces apoptosis of abnormal cells by cleaving intracellular proteins Homo sapiens ?
-
?
NuMA + H2O
-
Homo sapiens ?
-
?
PARP + H2O
-
Homo sapiens ?
-
?
PMS-1 + H2O
-
Homo sapiens ?
-
?
PMS-2 + H2O
-
Homo sapiens ?
-
?
pro-caspase-10 + H2O
-
Homo sapiens ?
-
?
pro-mCASP-3 + H2O
-
Homo sapiens caspase-3 + ?
-
?
pro-mCASP-7 + H2O
-
Homo sapiens caspase-7 + ?
-
?
topoisomerase-1 + H2O
-
Homo sapiens ?
-
?
U1-70kD + H2O
-
Homo sapiens ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.6
-
2-aminobenzoyl-VVAESSMESK-dnp pH 7.4, 37°C Homo sapiens
0.7
-
2-aminobenzoyl-IEPDSSMEK-dnp pH 7.4, 37°C, mutant K27A Homo sapiens
1.5
-
2-aminobenzoyl-VVADSSMESK-dnp pH 7.4, 37°C Homo sapiens
3.7
-
2-aminobenzoyl-VVADSSMASK-dnp pH 7.4, 37°C Homo sapiens
4.2
-
2-aminobenzoyl-IEPDSSMEK-dnp pH 7.4, 37°C, mutant K24A Homo sapiens
4.4
-
2-aminobenzoyl-IEPDSSMESK-dnp pH 7.4, 37°C Homo sapiens
4.4
-
2-aminobenzoyl-IEPDSSMEK-dnp pH 7.4, 37°C, wild-type Homo sapiens