Protein Variants | Comment | Organism |
---|---|---|
A339G | site-directed mutagenesis | Homo sapiens |
C335A | site-directed mutagenesis | Homo sapiens |
C341A | site-directed mutagenesis | Homo sapiens |
C341S | site-directed mutagenesis | Homo sapiens |
E340A | site-directed mutagenesis | Homo sapiens |
E340D | site-directed mutagenesis | Homo sapiens |
E344A | site-directed mutagenesis | Homo sapiens |
E344D | site-directed mutagenesis | Homo sapiens |
F336A | site-directed mutagenesis | Homo sapiens |
M343A | site-directed mutagenesis | Homo sapiens |
S334A | site-directed mutagenesis | Homo sapiens |
S345A | site-directed mutagenesis | Homo sapiens |
T327R | site-directed mutagenesis | Homo sapiens |
V337A | site-directed mutagenesis | Homo sapiens |
V338A | site-directed mutagenesis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
serpin proteinase inhibitor 9 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0058 | - |
2-aminobenzoyl-IEPDSSMESK-dnp | pH 7.4, 37°C | Homo sapiens | |
0.0058 | - |
2-aminobenzoyl-IEPDSSMEK-dnp | pH 7.4, 37°C, wild-type | Homo sapiens | |
0.0068 | - |
2-aminobenzoyl-IEPDSSMEK-dnp | pH 7.4, 37°C, mutant K24A | Homo sapiens | |
0.013 | - |
2-aminobenzoyl-VVADSSMESK-dnp | pH 7.4, 37°C | Homo sapiens | |
0.0387 | - |
2-aminobenzoyl-IEPDSSMEK-dnp | pH 7.4, 37°C, mutant K27A | Homo sapiens | |
0.0643 | - |
2-aminobenzoyl-VVAESSMESK-dnp | pH 7.4, 37°C | Homo sapiens | |
0.0701 | - |
2-aminobenzoyl-VVADSSMASK-dnp | pH 7.4, 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-PKcs + H2O | Homo sapiens | - |
? | - |
? | |
fibrillarin + H2O | Homo sapiens | - |
? | - |
? | |
La/SS-B + H2O | Homo sapiens | - |
? | - |
? | |
Mi-2 + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | induces apoptosis of abnormal cells by cleaving intracellular proteins | ? | - |
? | |
NuMA + H2O | Homo sapiens | - |
? | - |
? | |
PARP + H2O | Homo sapiens | - |
? | - |
? | |
PMS-1 + H2O | Homo sapiens | - |
? | - |
? | |
PMS-2 + H2O | Homo sapiens | - |
? | - |
? | |
pro-caspase-10 + H2O | Homo sapiens | - |
? | - |
? | |
pro-mCASP-3 + H2O | Homo sapiens | - |
caspase-3 + ? | - |
? | |
pro-mCASP-7 + H2O | Homo sapiens | - |
caspase-7 + ? | - |
? | |
topoisomerase-1 + H2O | Homo sapiens | - |
? | - |
? | |
U1-70kD + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-IEPDSSMEK-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-IEPDSSMESK-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-Val-Val-Ala-Asp-Ser-Ser-Met-Glu-Lys-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-Val-Val-Ala-Glu-Ser-Ser-Met-Glu-Lys-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-VVADSSMASK-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-VVADSSMESK-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-VVAESSMESK-dnp + H2O | - |
Homo sapiens | ? | - |
? | |
DNA-PKcs + H2O | - |
Homo sapiens | ? | - |
? | |
DNA-PKcs + H2O | directly and efficiently cleaved in vitro and in vivo, abolishes kinase activity | Homo sapiens | ? | - |
? | |
fibrillarin + H2O | - |
Homo sapiens | ? | - |
? | |
La/SS-B + H2O | - |
Homo sapiens | ? | - |
? | |
Mi-2 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | induces apoptosis of abnormal cells by cleaving intracellular proteins | Homo sapiens | ? | - |
? | |
NuMA + H2O | - |
Homo sapiens | ? | - |
? | |
PARP + H2O | - |
Homo sapiens | ? | - |
? | |
PMS-1 + H2O | - |
Homo sapiens | ? | - |
? | |
PMS-2 + H2O | - |
Homo sapiens | ? | - |
? | |
pro-caspase-10 + H2O | - |
Homo sapiens | ? | - |
? | |
pro-mCASP-3 + H2O | - |
Homo sapiens | caspase-3 + ? | - |
? | |
pro-mCASP-7 + H2O | - |
Homo sapiens | caspase-7 + ? | - |
? | |
topoisomerase-1 + H2O | - |
Homo sapiens | ? | - |
? | |
U1-70kD + H2O | - |
Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.6 | - |
2-aminobenzoyl-VVAESSMESK-dnp | pH 7.4, 37°C | Homo sapiens | |
0.7 | - |
2-aminobenzoyl-IEPDSSMEK-dnp | pH 7.4, 37°C, mutant K27A | Homo sapiens | |
1.5 | - |
2-aminobenzoyl-VVADSSMESK-dnp | pH 7.4, 37°C | Homo sapiens | |
3.7 | - |
2-aminobenzoyl-VVADSSMASK-dnp | pH 7.4, 37°C | Homo sapiens | |
4.2 | - |
2-aminobenzoyl-IEPDSSMEK-dnp | pH 7.4, 37°C, mutant K24A | Homo sapiens | |
4.4 | - |
2-aminobenzoyl-IEPDSSMESK-dnp | pH 7.4, 37°C | Homo sapiens | |
4.4 | - |
2-aminobenzoyl-IEPDSSMEK-dnp | pH 7.4, 37°C, wild-type | Homo sapiens |