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Literature summary for 3.4.21.79 extracted from

  • Odake, S.; Kam, C.M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C.
    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins (1991), Biochemistry, 30, 2217-2227.
    View publication on PubMed
Search for more literature for 3.4.21.79

Inhibitors

Inhibitors Comment Organism Structure
Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Asp-CH2Cl
-
 Homo sapiens
Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Asp-CH2Cl
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 Nalpha-tert-butyloxycarbonyl-Ala-Ala-Asp thiobenzyl ester mouse Mus musculus
0.55
-
 Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester mouse Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
CaCl2 50 mM, enhances Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl esterase activity Mus musculus
CaCl2 50 mM, enhances Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl esterase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cytotoxic T-cell
-
 Mus musculus
-
cytotoxic T-cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Asn thiobenzyl ester + H2O
-
 Mus musculus ?
-
 ?
Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O
-
 Mus musculus ?
-
 ?
Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O
-
 Homo sapiens ?
-
 ?
Nalpha-tert-Butyloxycarbonyl-L-Ala-Ala-Ser thiobenzyl ester + H2O
-
 Mus musculus ?
-
 ?
Nalpha-tert-Butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester + H2O
-
 Mus musculus ?
-
 ?
Nalpha-tert-Butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
24
-
 Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester mouse Mus musculus
116
-
 Nalpha-tert-butyloxycarbonyl-Ala-Ala-Asp thiobenzyl ester mouse Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5 Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester Mus musculus
7 7.5 Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester Homo sapiens