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Literature summary for 3.4.21.78 extracted from

  • Zhou, Z.; He, H.; Wang, K.; Shi, X.; Wang, Y.; Su, Y.; Wang, Y.; Li, D.; Liu, W.; Zhang, Y.; Shen, L.; Han, W.; Shen, L.; Ding, J.; Shao, F.
    Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells (2020), Science, 368, eaaz7548.
    View publication on PubMed
Search for more literature for 3.4.21.78

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cells with a C-terminal Flag tag Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin B + H2O Mus musculus granzyme A from cytotoxic lymphocytes cleaves gasdermin B (GSDMB) to trigger pyroptosis in target cells, predominantly at Lys244 within the interdomain linker. This cleavage unmaskes the pore-forming activity of GSDMB. Granzyme A, delivered into GSDMB-reconstituted cells by electroporation or perforin, induces extensive pyroptosis with interdomain cleavage of GSDMB ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P11032
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Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin B + H2O granzyme A from cytotoxic lymphocytes cleaves gasdermin B (GSDMB) to trigger pyroptosis in target cells, predominantly at Lys244 within the interdomain linker. This cleavage unmaskes the pore-forming activity of GSDMB. Granzyme A, delivered into GSDMB-reconstituted cells by electroporation or perforin, induces extensive pyroptosis with interdomain cleavage of GSDMB Mus musculus ?
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 ?
gasdermin B + H2O
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 Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
Gzma
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 Mus musculus

General Information

General Information Comment Organism
physiological function granzyme A from cytotoxic lymphocytes cleaves gasdermin B to trigger pyroptosis in target cells. This immune effector mechanism promotes cytotoxic T lymphocyte-mediated tumor clearance in mice Mus musculus