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Literature summary for 3.4.21.78 extracted from

  • Uranga, S.; Marinova, D.; Martin, C.; Pardo, J.; Aguilo, N.
    Granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis infection but does not contribute to protection in vivo (2016), PLoS ONE, 11, e0153028 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of GzmA-/- knockout mice, backcrossed into the C57BL/6 background more than 10 times Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P11032
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Mus musculus C57BL/6 P11032
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Source Tissue

Source Tissue Comment Organism Textmining
lung GZMA is expressed in lungs from wild-type and Mycobacterium tuberculosis-infected mice Mus musculus
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additional information most of the GZMA-positive cells (over 95%) in non-infected mice are positive for the NK1.1 surface marker with a small proportion of CD8+ and CD4+ T cells, indicating that in the absence of infection GZMA expression in lungs is mainly restricted to natural killer (NK) cells. Conversely, four weeks post-infection, percentage of NK1.1-positive GZMA-expressing cells decreases to 80%, due to the substantial increase observed in the percentage of GZMA-positive CD8+ and CD4+ T cells, (15% and 5%, respectively). In concurrence with these observations, both frequency and absolute number of CD4+ and CD8+ GZMA-expressing cells dramatically increase in lungs upon infection. Tuberculosis infection also leads to an increase in the number of GZMA-expressing NK cells Mus musculus
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natural killer cell
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Mus musculus
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neutrophil
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Mus musculus
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T-lymphocyte CD8+ and CD4+ cells Mus musculus
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Synonyms

Synonyms Comment Organism
Gzma
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Mus musculus

General Information

General Information Comment Organism
malfunction even though granzyme A is expressed by cytotoxic cells from mouse lungs during pulmonary infection, its deficiency in knockout mice does not have an effect in the control of Mycobacterium tuberculosis infection Mus musculus
physiological function granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis strain H37Rv infection but does not contribute to protection in vivo. Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis Mus musculus