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Literature summary for 3.4.21.78 extracted from

  • Kaiserman, D.; Stewart, S.E.; Plasman, K.; Gevaert, K.; Van Damme, P.; Bird, P.I.
    Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A (2014), J. Biol. Chem., 289, 9408-9417.
    View publication on PubMed
Search for more literature for 3.4.21.78

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme expression in Pichia pastoris Homo sapiens
recombinant enzyme expression in Pichia pastoris Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information substrate specificity-based screening for potential inhibitors from the intracellular serpin family, no enzyme inhibition by Serpinb6b Homo sapiens
additional information substrate specificity-based screening for potential inhibitors from the intracellular serpin family, overview. A lineage-specific increase in enzyme cytotoxic potential has driven cognate inhibitor evolution Mus musculus
Serpinb6b potent inhibitor, Serpinb6b employs an exosite to specifically inhibit dimeric but not monomeric murine enzyme. Kinetic analysis and modeling of the mGzmA-Serpinb6b Michaelis complex, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P12544
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Mus musculus
-
lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-GLFRSLSS(K-dnp)D + H2O a quenched fluorescence peptide substrate Mus musculus Abz-GLFR + SLSS(K-dnp)D
-
 ?
Abz-VANRSAS(Kdnp)D + H2O a quenched fluorescence peptide substrate Mus musculus Abz-VANR + SAS(Kdnp)D
-
 ?
additional information substrate specificity, comparison to the human enzyme at the peptide and proteome-wide levels, overview Mus musculus ?
-
 ?
additional information substrate specifiicty, comparison to the murine enzyme at the peptide and proteome-wide levels, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Gzm A
-
 Mus musculus
Gzm A
-
 Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the granzyme serine protease family, key effector molecules expressed by cytotoxic lymphocytes. Peptide substrate specificity profile of mouse and human granzyme A, overview Mus musculus
evolution the enzyme belongs to the granzyme serine protease family, key effector molecules expressed by cytotoxic lymphocytes. Peptide substrate specificity profile of mouse and human granzyme A, overview Homo sapiens
physiological function the murine enzyme shows a high cytotoxic potential in P815 mastocytoma target cells with streptolysin O Mus musculus
physiological function the human enzyme shows only slight cytotoxic potential in P815 mastocytoma target cells with streptolysin O Homo sapiens