Cloned (Comment) | Organism |
---|---|
recombinant enzyme expression in Pichia pastoris | Mus musculus |
recombinant enzyme expression in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | substrate specificity-based screening for potential inhibitors from the intracellular serpin family, no enzyme inhibition by Serpinb6b | Homo sapiens | |
additional information | substrate specificity-based screening for potential inhibitors from the intracellular serpin family, overview. A lineage-specific increase in enzyme cytotoxic potential has driven cognate inhibitor evolution | Mus musculus | |
Serpinb6b | potent inhibitor, Serpinb6b employs an exosite to specifically inhibit dimeric but not monomeric murine enzyme. Kinetic analysis and modeling of the mGzmA-Serpinb6b Michaelis complex, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12544 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | - |
Mus musculus | - |
lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-GLFRSLSS(K-dnp)D + H2O | a quenched fluorescence peptide substrate | Mus musculus | Abz-GLFR + SLSS(K-dnp)D | - |
? | |
Abz-VANRSAS(Kdnp)D + H2O | a quenched fluorescence peptide substrate | Mus musculus | Abz-VANR + SAS(Kdnp)D | - |
? | |
additional information | substrate specificity, comparison to the human enzyme at the peptide and proteome-wide levels, overview | Mus musculus | ? | - |
? | |
additional information | substrate specifiicty, comparison to the murine enzyme at the peptide and proteome-wide levels, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Gzm A | - |
Mus musculus |
Gzm A | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the granzyme serine protease family, key effector molecules expressed by cytotoxic lymphocytes. Peptide substrate specificity profile of mouse and human granzyme A, overview | Mus musculus |
evolution | the enzyme belongs to the granzyme serine protease family, key effector molecules expressed by cytotoxic lymphocytes. Peptide substrate specificity profile of mouse and human granzyme A, overview | Homo sapiens |
physiological function | the human enzyme shows only slight cytotoxic potential in P815 mastocytoma target cells with streptolysin O | Homo sapiens |
physiological function | the murine enzyme shows a high cytotoxic potential in P815 mastocytoma target cells with streptolysin O | Mus musculus |