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Literature summary for 3.4.21.78 extracted from

  • Arias, M.A.; Jimenez de Baguees, M.P.; Aguilo, N.; Menao, S.; Hervas-Stubbs, S.; de Martino, A.; Alcaraz, A.; Simon, M.M.; Froelich, C.J.; Pardo, J.
    Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis (2014), Cell Rep., 8, 420-429.
    View publication on PubMed
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Application

Application Comment Organism
medicine the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P11032 gene gzmA
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Mus musculus B6 P11032 gene gzmA
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Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
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natural killer cell
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 Mus musculus
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spleen
-
 Mus musculus
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General Information

General Information Comment Organism
physiological function wild-type and granzyme A-deficient mice eliminate the mouse pathogen Brucella microti from liver and spleen within 2 or 3 weeks, whereas the bacteria persist in mice lacking perforin or granzyme B as well as in mice depleted of Tc cells. Only gzmA-/- mice exhibit increased survival, which correlated with reduced proinflammatory cytokines, due to depletion of natural killer cells. Infection-related pathology, but not bacterial clearance, appears to require the enzyme Mus musculus