Application | Comment | Organism |
---|---|---|
medicine | the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P11032 | gene gzmA | - |
Mus musculus B6 | P11032 | gene gzmA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
natural killer cell | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | wild-type and granzyme A-deficient mice eliminate the mouse pathogen Brucella microti from liver and spleen within 2 or 3 weeks, whereas the bacteria persist in mice lacking perforin or granzyme B as well as in mice depleted of Tc cells. Only gzmA-/- mice exhibit increased survival, which correlated with reduced proinflammatory cytokines, due to depletion of natural killer cells. Infection-related pathology, but not bacterial clearance, appears to require the enzyme | Mus musculus |