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Literature summary for 3.4.21.78 extracted from
- A novel and divergent role of granzyme A and B in resistance to helminth infection (2011), J. Immunol., 186, 2472-2481.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | proinflammatory gzmA and anti-inflammatory gzmB are novel modulators of the Th1/2 balance and defense in helminth infection | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in filarial infection with Litomosoides sigmodontis, worm loads are significantly reduced in gzmA/gzmB and in gzmB knockout mice during the whole course of infection, but enhanced only early in gzmA knockout compared with wild-type mice. GzmA/gzmB deficiency is associated with a defense-promoting Th2 cytokine and Ab shift, enhanced early inflammatory gene expression, and a trend of reduced alternatively activated macrophage induction, whereas gzmA deficiency is linked with reduced inflammation and a trend toward increased alternatively activated macrophages | Mus musculus |
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