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Literature summary for 3.4.21.78 extracted from
- Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy (2007), J. Hum. Genet., 52, 328-333.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | glucocorticoid treatment markedly enhances granzyme A expression in glucocorticoid-sensitive but not in glucocorticoid-resistant cell lines | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | investigation of glucocorticoid-induced expression of granzyme A as a potential early biomarker for personalized therapy of acute lymphoblastic leukemia patients | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P12544 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| acute lymphoblastic leukemia cell line | acute lymphoblastic leukemia-derived cell line 697 used as a positive control, granzyme A mediated glucocorticoid-induced apoptosis shown | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
glucocorticoid sensitivity among cell lines derived from acute lymphoblastic leukemia patients analyzed, correlation between glucocorticoid-induced apoptosis and glucocorticoid-induced mRNA expression of granzyme A shown | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Gzma | - |
Homo sapiens |
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