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Literature summary for 3.4.21.78 extracted from

  • Hochegger, K.; Eller, P.; Huber, J.M.; Bernhard, D.; Mayer, G.; Zlabinger, G.J.; Rosenkranz, A.R.
    Expression of granzyme A in human polymorphonuclear neutrophils (2007), Immunology, 121, 166-173.
    View publication on PubMed
Search for more literature for 3.4.21.78

Activating Compound

Activating Compound Comment Organism Structure
additional information stimulation with opsonized Escherichia coli or the bioincompatible haemodialysis membrane cuprophane reveals up-regulation of granzyme A expression at transcriptional and translational levels Homo sapiens

Application

Application Comment Organism
medicine studies on the role of granzyme A in polymorphonuclear neutrophils (PMNs) in defence against invading pathogens Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule subcellular fractionation, granzyme A in peroxidase-negative granules identified Homo sapiens 30141
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Organism

Organism UniProt Comment Textmining
Homo sapiens P12544
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell no expression of granzyme A in promyelocytic cell line HL-60 identified Homo sapiens
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leukocyte whole-blood leucocyte preparation discriminating between the distinct subpopulations, expression in CD8+ CTLs and in CD56+ NK cells shown Homo sapiens
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peripheral blood mononuclear cell PBMCs, expression in Homo sapiens
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polymorphonuclear leukocyte PMNs, polymorphonuclear neutrophils, expression in CD15+ population identified, differentiated cell stage, phagocytic stimuli of PMNs increase expression Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 expression shown by flow cytometry, Western blot, enzyme-linked immunosorbent assay and quantitative RT-PCR, up-regulation of expression upon stimulation shown Homo sapiens
additional information
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 constitutive expression in human PMNs shown by flow cytometry, Western blot, enzyme-linked immunosorbent assay and quantitative RT-PCR, up-regulation upon PMN stimulation shown Homo sapiens
additional information
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 expression shown by flow cytometry, Western blot, enzyme-linked immunosorbent assay and quantitative RT-PCR, up-regulation upon stimulation shown Homo sapiens

Synonyms

Synonyms Comment Organism
Gzma
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 Homo sapiens