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Literature summary for 3.4.21.78 extracted from

  • Baschuk, N.; Utermoehlen, O.; Gugel, R.; Warnecke, G.; Karow, U.; Paulsen, D.; Brombacher, F.; Kroenke, M.; Deppert, W.
    Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice (2007), Cancer Immunol. Immunother., 56, 1625-1636.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus P11032 granzyme A precursor; interleukin 4-deficient BALB/c mice and wild-type BALB/c controls
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Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte lysates of CD8+ tumor associated lymphocytes, Interleukin 4-deficient mice Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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enzymatic activity of granzyme A measured in lysates of CD8+ tumor associated lymphocytes of interleukin 4-deficient and wild-type BALB/c mice, significant increase in the fraction of CD8+ tumor associated T-cells expressing granzyme A identified, in interleukin 4-deficient mice, the frequency of CD8+ tumor associated lymphocytes expressing granzyme A significantly increases between days 8 and 14, expression at background levels by day 21, increase in the percentage of CD8+ tumor associated lymphocytes expressing granzyme A less pronounced in wild-type mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H-D-Pro-Phe-Arg p-nitroanilide + H2O i.e. S2302, measurement of enzymatic activity of granzyme A activity in lysates of CD8+ TAL Mus musculus H-D-Pro-Phe-Arg + p-nitroaniline
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N-acetyl-Ile-Glu-Pro-Asp p-nitroanilide + H2O measurement of enzymatic activity of granzyme A activity in lysates of CD8+ TAL Mus musculus N-acetyl-Ile-Glu-Pro-Asp + p-nitroaniline
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