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Literature summary for 3.4.21.78 extracted from

  • Buzza, M.S.; Bird, P.I.
    Extracellular granzymes: current perspectives (2006), Biol. Chem., 387, 827-837.
    View publication on PubMed
Search for more literature for 3.4.21.78

Application

Application Comment Organism
medicine role of extracellular granzymes in disease reviewed Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibited by the extracellular serpins anti-thrombin III and C1-inhibitor and by the non-serpin inhibitor alpha2-macroglobulin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular extracellular functions and mechanisms for escape into the extracellular environment reviewed Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P12544
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 detection of extracellular granzyme A during disease reviewed, elevated levels during viral and bacterial infection, arthritis and other diseases Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information extracellular substrates of granzyme A and proposed functions summarized, pathological consequences of extracellular granzyme A in disease reviewed, role of anionic interactions in extracellular substrate binding summarized, evidence for the role of glycosaminoglycan-binding sites of granzyme A in extracellular matrix remodelling described Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GrA
-
 Homo sapiens