Literature summary for 3.4.21.78 extracted from

Pardo, J.; Bosque, A.; Brehm, R.; Wallich, R.; Naval, J.; Mullbacher, A.; Anel, A.; Simon, M.M.
Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis (2004), J. Cell Biol., 167, 457-468.

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Application

Application	Comment	Organism
medicine	cytolytic T-lymphocytes from enzyme or granzyme B deficient mice similarly induce early proapoptotic features such as phosphatidyl serine exposure on plasma membrane, or reactive oxygen radical generation, though with distinct kinetics. Cytolytic T-lymphocytes from granzyme A, but not granzyme B deficient animals activate caspase 3 and 9. All granzyme-induced apoptotic features depend critically on perforin	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	homozygous deficiency in enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-lymphocyte	-	Mus musculus	-

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Release 2026.1 (March 2026)