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Literature summary for 3.4.21.78 extracted from

  • Grossman, W.J.; Verbsky, J.W.; Tollefsen, B.L.; Kemper, C.; Atkinson, J.P.; Ley, T.J.
    Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells (2004), Blood, 104, 2840-2848.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte cytotoxic lymphocyte subsets and T regulatory cells, most circulating CD56+8- NK cells and half of circulating CD8+ T lymphocytes coexpress both granzymes A and B. Activation of CD8+ T-lymphocytes with concanavalin A and of CD4+ T-lymphocytes with antibodies to CD3/CD28 or CD3/CD46 induces substantial expression of granzyme B, but not of granzyme A Homo sapiens
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