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Literature summary for 3.4.21.78 extracted from

  • Spaeny-Dekking, E.H.A.; Kamp, A.M.; Froelich, C.J.; Hack, C.E.
    Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors (2000), Blood, 95, 1465-1472.
    View publication on PubMed
Search for more literature for 3.4.21.78

Application

Application Comment Organism
medicine diagnosis tool, patients with various viral diseases or with rheumatic arthritis have elevated levels of circulating granzyme A Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
HepG2 cells infected with granzyme A recombinant vaccinia virus Homo sapiens

General Stability

General Stability Organism
extracellular granzyme A circulates in the mature conformation and is bound to proteoglycans that protect it against inactivation by protease inhibitors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-2-Macroglobulin
-
 Homo sapiens
antithrombin III
-
 Homo sapiens
phenylmethylsulfonyl fluoride
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000 30000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens most abundant protease in cytotoxic T lymphocytes, granzyme A pathway of cell-mediated cytotoxicity, produced as proenzyme, activated by the dipetidyl exopeptidase cathepsin C ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein proteoglycans containing glycosaminoglycan, various forms of extracellular granzyme A occur in vivo, the regulation of activity may be modified by proteoglycans Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information most abundant protease in cytotoxic T lymphocytes, granzyme A pathway of cell-mediated cytotoxicity, produced as proenzyme, activated by the dipetidyl exopeptidase cathepsin C Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GrA
-
 Homo sapiens