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Literature summary for 3.4.21.78 extracted from

  • Vettel, U.; Brunner, G.; Bar-Shavit, R.; Vlodavsky, I.; Kramer, M.D.
    Charge-dependent binding of granzyme A (MTSP-1) to basement membranes (1993), Eur. J. Immunol., 23, 279-282.
    View publication on PubMed
Search for more literature for 3.4.21.78

Inhibitors

Inhibitors Comment Organism Structure
Natural high MW inhibitors binding to charged surfaces protects the enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme binds to natural basement membranes in a charge-dependent manner Mus musculus
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secretory granule intracellular Mus musculus 30141
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus by cleaving a variety of basement membrane-associated substrates, granzyme A may disintegrate the supramolecular structure of subendothelial basement membranes in a way that allows a more rapid emigration of activated T-cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information by cleaving a variety of basement membrane-associated substrates, granzyme A may disintegrate the supramolecular structure of subendothelial basement membranes in a way that allows a more rapid emigration of activated T-cells Mus musculus ?
-
 ?