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Literature summary for 3.4.21.78 extracted from
- Granzyme A (1994), Methods Enzymol., 244, 68-79.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha1-proteinase inhibitor | - |
Homo sapiens | |
| alpha2-Macroglobulin | - |
Homo sapiens | |
| alpha2-Macroglobulin | - |
Mus musculus | |
| antithrombin III | - |
Homo sapiens | |
| antithrombin III | - |
Mus musculus | |
| Aprotinin | - |
Homo sapiens |  |
| Aprotinin | - |
Mus musculus | |
| benzamidine | - |
Homo sapiens | |
| benzamidine | - |
Mus musculus | |
| C1 esterase inhibitor | - |
Mus musculus | |
| D-Pro-Phe-Arg-CH2Cl | - |
Mus musculus | |
| diisopropyl fluorophosphate | - |
Homo sapiens | |
| diisopropyl fluorophosphate | - |
Mus musculus | |
| leupeptin | - |
Homo sapiens | |
| leupeptin | - |
Mus musculus | |
| phenylmethanesulfonyl fluoride | - |
Homo sapiens | |
| phenylmethanesulfonyl fluoride | - |
Mus musculus | |
| Protease nexin-1 | - |
Mus musculus | |
| Soybean trypsin inhibitor | - |
Homo sapiens | |
| Soybean trypsin inhibitor | - |
Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | of effector cells | Homo sapiens | 5737 | - |
| cytoplasm | of effector cells | Mus musculus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | ? | - |
? | |
| additional information | Homo sapiens | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | enriched cytoplasmic granules | Homo sapiens | - |
| additional information | enriched cytoplasmic granules | Mus musculus | - |
| T-lymphocyte | cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes | Homo sapiens | - |
| T-lymphocyte | cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Mus musculus | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
| benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
| D-Pro-Phe-Arg 4-nitroanilide + H2O | - |
Mus musculus | D-Pro-Phe-Arg + 4-nitroaniline | - |
? | |
| Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | Mus musculus | ? | - |
? | |
| additional information | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | Homo sapiens | ? | - |
? | |
| Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Mus musculus | ? | - |
? | |
| Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
| Tosyl-Gly-Pro-Arg 4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively | Homo sapiens |
| dimer | enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | D-Pro-Phe-Arg 4-nitroanilide, mouse enzyme | Mus musculus |
| 8 | - |
Gly-Pro-Arg 4-methylcoumarin 7-amide, human enzyme | Homo sapiens |
| 11 | - |
tosyl-Gly-Pro-Arg 4-nitroanilide, human enzyme | Homo sapiens |
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