BRENDA - Enzyme Database show
show all sequences of 3.4.21.78

Granzyme A

Simon, M.M.; Kramer, M.D.; Methods Enzymol. 244, 68-79 (1994)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Homo sapiens
-
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Alpha1-proteinase inhibitor
-
Homo sapiens
alpha2-Macroglobulin
-
Homo sapiens
alpha2-Macroglobulin
-
Mus musculus
antithrombin III
-
Mus musculus
antithrombin III
-
Homo sapiens
Aprotinin
-
Homo sapiens
Aprotinin
-
Mus musculus
benzamidine
-
Mus musculus
benzamidine
-
Homo sapiens
C1 esterase inhibitor
-
Mus musculus
D-Pro-Phe-Arg-CH2Cl
-
Mus musculus
diisopropyl fluorophosphate
-
Homo sapiens
diisopropyl fluorophosphate
-
Mus musculus
leupeptin
-
Homo sapiens
leupeptin
-
Mus musculus
phenylmethanesulfonyl fluoride
-
Homo sapiens
phenylmethanesulfonyl fluoride
-
Mus musculus
Protease nexin-1
-
Mus musculus
Soybean trypsin inhibitor
-
Homo sapiens
Soybean trypsin inhibitor
-
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
of effector cells
Homo sapiens
5737
-
cytoplasm
of effector cells
Mus musculus
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
?
-
-
-
additional information
Homo sapiens
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Mus musculus
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
enriched cytoplasmic granules
Homo sapiens
-
additional information
enriched cytoplasmic granules
Mus musculus
-
T-lymphocyte
cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes
Homo sapiens
-
T-lymphocyte
cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
29737
Mus musculus
?
-
-
-
-
Benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
29737
Homo sapiens
?
-
-
-
-
D-Pro-Phe-Arg 4-nitroanilide + H2O
-
29737
Mus musculus
D-Pro-Phe-Arg + 4-nitroaniline
-
-
-
-
Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
29737
Homo sapiens
?
-
-
-
-
additional information
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
29737
Mus musculus
?
-
-
-
-
additional information
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
29737
Homo sapiens
?
-
-
-
-
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
29737
Mus musculus
?
-
-
-
-
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
29737
Homo sapiens
?
-
-
-
-
Tosyl-Gly-Pro-Arg 4-nitroanilide + H2O
-
29737
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively
Homo sapiens
dimer
enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.5
D-Pro-Phe-Arg 4-nitroanilide, mouse enzyme
Mus musculus
8
-
Gly-Pro-Arg 4-methylcoumarin 7-amide, human enzyme
Homo sapiens
11
-
tosyl-Gly-Pro-Arg 4-nitroanilide, human enzyme
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Alpha1-proteinase inhibitor
-
Homo sapiens
alpha2-Macroglobulin
-
Homo sapiens
alpha2-Macroglobulin
-
Mus musculus
antithrombin III
-
Mus musculus
antithrombin III
-
Homo sapiens
Aprotinin
-
Homo sapiens
Aprotinin
-
Mus musculus
benzamidine
-
Mus musculus
benzamidine
-
Homo sapiens
C1 esterase inhibitor
-
Mus musculus
D-Pro-Phe-Arg-CH2Cl
-
Mus musculus
diisopropyl fluorophosphate
-
Homo sapiens
diisopropyl fluorophosphate
-
Mus musculus
leupeptin
-
Homo sapiens
leupeptin
-
Mus musculus
phenylmethanesulfonyl fluoride
-
Homo sapiens
phenylmethanesulfonyl fluoride
-
Mus musculus
Protease nexin-1
-
Mus musculus
Soybean trypsin inhibitor
-
Homo sapiens
Soybean trypsin inhibitor
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
of effector cells
Homo sapiens
5737
-
cytoplasm
of effector cells
Mus musculus
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
?
-
-
-
additional information
Homo sapiens
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Mus musculus
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
enriched cytoplasmic granules
Homo sapiens
-
additional information
enriched cytoplasmic granules
Mus musculus
-
T-lymphocyte
cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes
Homo sapiens
-
T-lymphocyte
cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
29737
Mus musculus
?
-
-
-
-
Benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
29737
Homo sapiens
?
-
-
-
-
D-Pro-Phe-Arg 4-nitroanilide + H2O
-
29737
Mus musculus
D-Pro-Phe-Arg + 4-nitroaniline
-
-
-
-
Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
29737
Homo sapiens
?
-
-
-
-
additional information
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
29737
Mus musculus
?
-
-
-
-
additional information
overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection
29737
Homo sapiens
?
-
-
-
-
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
29737
Mus musculus
?
-
-
-
-
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
29737
Homo sapiens
?
-
-
-
-
Tosyl-Gly-Pro-Arg 4-nitroanilide + H2O
-
29737
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively
Homo sapiens
dimer
enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.5
D-Pro-Phe-Arg 4-nitroanilide, mouse enzyme
Mus musculus
8
-
Gly-Pro-Arg 4-methylcoumarin 7-amide, human enzyme
Homo sapiens
11
-
tosyl-Gly-Pro-Arg 4-nitroanilide, human enzyme
Homo sapiens
Other publictions for EC 3.4.21.78
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731617
Arias
Elucidating sources and roles ...
Mus musculus, Mus musculus B6
Cell Rep.
8
420-429
2014
-
1
-
-
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6
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3
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1
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3
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-
-
-
-
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1
1
-
-
-
732177
Kaiserman
Identification of Serpinb6b as ...
Homo sapiens, Mus musculus
J. Biol. Chem.
289
9408-9417
2014
-
-
2
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-
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3
-
-
-
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4
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2
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4
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2
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3
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2
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-
4
-
-
-
-
-
-
-
-
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4
4
-
-
-
717504
Ilzecka
Granzymes A and B levels in se ...
Homo sapiens
Clin. Biochem.
44
650-653
2011
-
1
-
-
-
-
-
-
-
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2
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1
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1
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1
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-
-
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-
-
-
-
-
-
-
-
-
-
717675
Grodzovski
IL-2-granzyme A chimeric prote ...
Homo sapiens
Int. J. Cancer
128
1966-1980
2011
-
1
1
-
1
-
-
-
-
-
-
-
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2
-
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-
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1
1
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1
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-
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717939
Hartmann
A novel and divergent role of ...
Mus musculus
J. Immunol.
186
2472-2481
2011
-
1
-
-
-
-
-
-
-
-
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5
-
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1
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-
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-
-
-
-
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1
1
-
-
-
708274
Yoshikawa
Granzyme A and thrombin differ ...
Homo sapiens
Cytotechnology
62
325-332
2010
-
-
1
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
1
-
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-
717310
Van Damme
The substrate specificity prof ...
Homo sapiens
Biol. Chem.
391
983-997
2010
-
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1
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-
-
-
-
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2
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1
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1
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1
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1
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1
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717616
Huang
Identification and characteriz ...
Cyprinus carpio
Fish Shellfish Immunol.
29
388-398
2010
-
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-
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3
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11
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11
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1
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1
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-
697233
Martinvalet
Granzyme A cleaves a mitochond ...
Homo sapiens
Cell
133
681-692
2008
1
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1
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1
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3
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1
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1
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2
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2
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2
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683058
Vernooy
Increased granzyme A expressio ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
175
464-472
2007
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1
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2
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5
1
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1
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5
1
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2
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683270
Hirayasu
A role of a lymphocyte tryptas ...
Rattus norvegicus
Biosci. Biotechnol. Biochem.
71
234-237
2007
-
-
-
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2
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3
1
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1
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683326
Baschuk
Interleukin-4 impairs granzyme ...
Mus musculus
Cancer Immunol. Immunother.
56
1625-1636
2007
-
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-
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3
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1
1
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1
1
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2
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683529
Hochegger
Expression of granzyme A in hu ...
Homo sapiens
Immunology
121
166-173
2007
1
1
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-
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1
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3
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5
1
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1
1
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1
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5
1
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683723
Myoumoto
Glucocorticoid-induced granzym ...
Homo sapiens
J. Hum. Genet.
52
328-333
2007
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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1
1
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1
1
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1
1
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683789
Lee-Kirsch
A mutation in TREX1 that impai ...
Homo sapiens
J. Mol. Med.
85
531-537
2007
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1
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-
-
-
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-
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1
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1
1
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1
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1
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1
1
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1
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