Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-Amidinophenyl)-methanesulfonyl fluoride | - |
Homo sapiens | |
3,4-dichloroisocoumarin | poor | Homo sapiens | |
3,4-dichloroisocoumarin | poor | Mus musculus | |
Aprotinin | - |
Homo sapiens | |
Aprotinin | - |
Mus musculus | |
benzamidine | - |
Homo sapiens | |
benzamidine | - |
Mus musculus | |
diisopropyl fluorophosphate | - |
Homo sapiens | |
diisopropyl fluorophosphate | - |
Mus musculus | |
Isocoumarins | mechanism-based isocoumarin inhibitors substituted with basic guanidino or isothiureidopropoxy groups | Homo sapiens | |
Isocoumarins | mechanism-based isocoumarin inhibitors substituted with basic guanidino or isothiureidopropoxy groups | Mus musculus | |
leupeptin | - |
Homo sapiens | |
leupeptin | - |
Mus musculus | |
phenylmethanesulfonyl fluoride | - |
Homo sapiens | |
phenylmethanesulfonyl fluoride | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.105 | - |
benzyloxycarbonyl-Gly-Arg thiobenzyl ester | human granzyme A | Homo sapiens | |
0.12 | - |
benzyloxycarbonyl-Arg thiobenzyl ester | human granzyme A | Homo sapiens | |
0.13 | - |
benzyloxycarbonyl-Lys thiobenzyl ester | mouse enzyme | Mus musculus | |
0.14 | - |
tert-butyloxycarbonyl-Ala-Ala-Arg thiobenzyl ester | mouse enzyme | Mus musculus | |
0.16 | - |
benzyloxycarbonyl-Gly-Arg thiobenzyl ester | mouse enzyme | Mus musculus | |
0.19 | - |
benzyloxycarbonyl-Lys thiobenzyl ester | human granzyme A | Homo sapiens | |
0.315 | - |
benzyloxycarbonyl-Arg thiobenzyl ester | mouse enzyme | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | cytotoxic | Mus musculus | - |
T-lymphocyte | cytotoxic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Benzyloxycarbonyl-Arg thiobenzyl ester + H2O | - |
Mus musculus | ? | - |
? | |
Benzyloxycarbonyl-Arg thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Arg thiobenzyl ester + H2O | - |
Mus musculus | benzyloxycarbonyl-Gly-Arg + phenylmethanethiol | - |
? | |
benzyloxycarbonyl-Gly-Arg thiobenzyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Gly-Arg + phenylmethanethiol | - |
? | |
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Mus musculus | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
Boc-Ala-Ala-Arg-SBzl + H2O | - |
Mus musculus | ? | - |
? | |
D-(epsilon-Benzyloxycarbonyl)Lys-Pro-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Mus musculus | ? | - |
? | |
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Val-Pro-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Mus musculus | |
additional information | - |
additional information | - |
Homo sapiens | |
3.1 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | human granzyme A | Homo sapiens | |
5.83 | - |
benzyloxycarbonyl-Gly-Arg thiobenzyl ester | human granzyme A | Homo sapiens | |
8.8 | - |
benzyloxycarbonyl-Arg thiobenzyl ester | human granzyme A | Homo sapiens | |
21 | - |
benzyloxycarbonyl-Lys thiobenzyl ester | mouse enzyme | Mus musculus | |
45 | - |
tert-butyloxycarbonyl-Ala-Ala-Arg thiobenzyl ester | mouse enzyme | Mus musculus | |
59 | - |
benzyloxycarbonyl-Gly-Arg thiobenzyl ester | mouse enzyme | Mus musculus | |
83 | - |
benzyloxycarbonyl-Arg thiobenzyl ester | mouse enzyme | Mus musculus |