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Literature summary for 3.4.21.78 extracted from

  • Odake, S.; Kam, C.M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C.
    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins (1991), Biochemistry, 30, 2217-2227.
    View publication on PubMed
Search for more literature for 3.4.21.78

Inhibitors

Inhibitors Comment Organism Structure
(4-Amidinophenyl)-methanesulfonyl fluoride
-
 Homo sapiens
3,4-dichloroisocoumarin poor Homo sapiens
3,4-dichloroisocoumarin poor Mus musculus
Aprotinin
-
 Homo sapiens
Aprotinin
-
 Mus musculus
benzamidine
-
 Homo sapiens
benzamidine
-
 Mus musculus
diisopropyl fluorophosphate
-
 Homo sapiens
diisopropyl fluorophosphate
-
 Mus musculus
Isocoumarins mechanism-based isocoumarin inhibitors substituted with basic guanidino or isothiureidopropoxy groups Homo sapiens
Isocoumarins mechanism-based isocoumarin inhibitors substituted with basic guanidino or isothiureidopropoxy groups Mus musculus
leupeptin
-
 Homo sapiens
leupeptin
-
 Mus musculus
phenylmethanesulfonyl fluoride
-
 Homo sapiens
phenylmethanesulfonyl fluoride
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.105
-
 benzyloxycarbonyl-Gly-Arg thiobenzyl ester human granzyme A Homo sapiens
0.12
-
 benzyloxycarbonyl-Arg thiobenzyl ester human granzyme A Homo sapiens
0.13
-
 benzyloxycarbonyl-Lys thiobenzyl ester mouse enzyme Mus musculus
0.14
-
 tert-butyloxycarbonyl-Ala-Ala-Arg thiobenzyl ester mouse enzyme Mus musculus
0.16
-
 benzyloxycarbonyl-Gly-Arg thiobenzyl ester mouse enzyme Mus musculus
0.19
-
 benzyloxycarbonyl-Lys thiobenzyl ester human granzyme A Homo sapiens
0.315
-
 benzyloxycarbonyl-Arg thiobenzyl ester mouse enzyme Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte cytotoxic Homo sapiens
-
T-lymphocyte cytotoxic Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Benzyloxycarbonyl-Arg thiobenzyl ester + H2O
-
 Mus musculus ?
-
 ?
Benzyloxycarbonyl-Arg thiobenzyl ester + H2O
-
 Homo sapiens ?
-
 ?
benzyloxycarbonyl-Gly-Arg thiobenzyl ester + H2O
-
 Mus musculus benzyloxycarbonyl-Gly-Arg + phenylmethanethiol
-
 ?
benzyloxycarbonyl-Gly-Arg thiobenzyl ester + H2O
-
 Homo sapiens benzyloxycarbonyl-Gly-Arg + phenylmethanethiol
-
 ?
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
 Mus musculus benzyloxycarbonyl-Lys + phenylmethanethiol
-
 ?
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
 Homo sapiens benzyloxycarbonyl-Lys + phenylmethanethiol
-
 ?
Boc-Ala-Ala-Arg-SBzl + H2O
-
 Mus musculus ?
-
 ?
D-(epsilon-Benzyloxycarbonyl)Lys-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Mus musculus ?
-
 ?
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
additional information
-
 additional information
-
 Mus musculus
3.1
-
 Benzyloxycarbonyl-Lys-thiobenzyl ester human granzyme A Homo sapiens
5.83
-
 benzyloxycarbonyl-Gly-Arg thiobenzyl ester human granzyme A Homo sapiens
8.8
-
 benzyloxycarbonyl-Arg thiobenzyl ester human granzyme A Homo sapiens
21
-
 benzyloxycarbonyl-Lys thiobenzyl ester mouse enzyme Mus musculus
45
-
 tert-butyloxycarbonyl-Ala-Ala-Arg thiobenzyl ester mouse enzyme Mus musculus
59
-
 benzyloxycarbonyl-Gly-Arg thiobenzyl ester mouse enzyme Mus musculus
83
-
 benzyloxycarbonyl-Arg thiobenzyl ester mouse enzyme Mus musculus