Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.77 extracted from

  • Conway, R.E.; Joiner, K.; Patterson, A.; Bourgeois, D.; Rampp, R.; Hannah, B.C.; McReynolds, S.; Elder, J.M.; Gilfilen, H.; Shapiro, L.H.
    Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2 (2013), Angiogenesis, 16, 847-860.
    View publication on PubMed
Search for more literature for 3.4.21.77

Activating Compound

Activating Compound Comment Organism Structure
CVAYCIEHHCWTC
-
 Homo sapiens
CVFAHNYDYLVC
-
 Homo sapiens

Application

Application Comment Organism
diagnostics the ratio of phosphorylated/dephosphorylated galectin-3 might be used as a complementary value to that of prostate specific antigene for prognosis of prostate cancer and another therapeutic target for the treatment of prostate cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Galectin-3 + H2O Homo sapiens galectin-3 Tyr-107 is phosphorylated by c-Abl. It can be cleaved at this site by the enzyme after Tyr107, resulting in loss of galectin-3 multivalency while preserving its carbohydrate binding activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07288
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
LNCAP-C4-2B cell
-
 Homo sapiens
-
PC-3M cell
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Galectin-3 + H2O
-
 Homo sapiens ?
-
 ?
Galectin-3 + H2O galectin-3 Tyr-107 is phosphorylated by c-Abl. It can be cleaved at this site by the enzyme after Tyr107, resulting in loss of galectin-3 multivalency while preserving its carbohydrate binding activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
prostate-specific antigen
-
 Homo sapiens
PSA
-
 Homo sapiens

General Information

General Information Comment Organism
additional information the enzyme is a chymotrypsin-like serine protease Homo sapiens