Application | Comment | Organism |
---|---|---|
medicine | development of a water-soluble paclitaxel prodrug that is activated specifically by PSA. epsilon-Maleimidocaproyl-Arg-Ser-Ser-Tyr-Tyr-Ser-Leu-p-aminobenzyloxycarbonyl-paclitaxel is water-soluble and is bound to endogenous and exogenous albumin. The albumin-bound form of the prodrug is cleaved rapidly at the P1-P1' scissile bond releasing the paclitaxel-dipeptide Ser-Leu-p-aminobenzyloxycarbonyl-paclitaxel. Due to the incorporation of a p-aminobenzyloxycarbonyl self-eliminating linker, this dipeptide is rapidly degraded to liberate paclitaxel as a final cleavage product within a few hours in prostate tumour tissue homogenates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate | and prostate cancer tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
epsilon-maleimidocaproyl-Arg-Ser-Ser-Tyr-Tyr-Ser-Leu-p-aminobenzyloxycarbonyl-paclitaxel + H2O | water soluble paclitaxel prodrug that is activated specifically by PSA in prostate tissue and prostate carcinoma | Homo sapiens | epsilon-maleimidocaproyl-Arg-Ser-Ser-Tyr-Tyr + Ser-Leu-p-aminobenzyloxycarbonyl-paclitaxel | - |
? |