Literature summary for 3.4.21.77 extracted from

Vollmer, R.T.
Dissecting the dynamics of serum prostate-specific antigen (2010), Am. J. Clin. Pathol., 133, 187-193.

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Application

Application	Comment	Organism
medicine	analysis of values of serum prostate-specific antigen PSA in American Veterans during the time before their diagnosis of prostate cancer. The values appear to follow an exponential model with respect to time. The model comprises a sum of two exponential functions, one for an early, slowly rising component of PSA and a second for a later, faster rising component. The relative velocity of the slow component is significantly associated with the volume of benign tissue, both the amplitude and relative velocity of the fast component are significantly associated with the volume of tumor. At the time of diagnosis of prostate cancer the level and velocity of PSA reflect the combination of slow and fast components. The model provides insight into how benign and malignant tissues in the prostate determine the dynamics of PSA	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	American veterans before diagnosis of prostate cancer	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

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Release 2023.1 (January 2023)