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Literature summary for 3.4.21.77 extracted from
- Complex formation between human prostate-specific antigen and protease inhibitors in mouse plasma (2010), Prostate, 70, 482-490.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
Western blotting of PSA-spiked mouse serum | Homo sapiens |
| 65000 | - |
Western blotting of PSA-spiked mouse serum | Homo sapiens |
| 85000 | - |
Western blotting of PSA-spiked mouse serum | Homo sapiens |
| 160000 | - |
Western blotting of PSA-spiked mouse serum | Homo sapiens |
| 200000 | - |
Western blotting of PSA-spiked mouse serum | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| free and complexed PSA, by gel filtration and immunoadsorption | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 22Rv1 cell | - |
Homo sapiens | - |
| LNCaP cell | - |
Homo sapiens | - |
| seminal plasma | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prostate-specific antigen | - |
Homo sapiens |
| PSA | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | LNCaP and 22RV1 xenograft tumors express PSA | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in mice bearing xenograft tumors, 68% of the immunoreactive PSA occurrs in complex. After 18 h most of PSA added to mouse and human serum is also complexed: and when added to mouse serum, over 70% of PSA forms complexes that comprises alpha2-macroglobulin and members of the alpha1-antitrypsin family. The complex formation of PSA produced by xenograft tumor models in mice is similar to that of human prostate tumors with respect to the complexation of PSA. Circulating levels of PSA in mice bearing LNCaP and 22RV1 xenograft tumors correlate with tumor volume: concentration of total and free PSA decreases rapidly as a result of complex formation | Homo sapiens |
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Release 2023.1 (January 2023)
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