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Literature summary for 3.4.21.77 extracted from

  • Voeghtly, L.M.; Thogersen, I.B.; Valnickova, Z.; Sanggaard, K.W.; Chu, C.T.; Oury, T.D.; Enghild, J.J.
    Potential clinical importance of the activation peptide of prostate-specific antigen (2009), Int. J. Clin. Exp. Pathol., 2, 588-598.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information PSA-alpha1-antichymotrypsin complex is cleared from the blood, but as its concentration increases its clearance mechanism becomes saturated and only then do the PSA-alpha1-antichymotrypsin complexes accumulate in the blood Homo sapiens

Application

Application Comment Organism
medicine urine detection of the PSA activation peptide may represent a clinically sensitive measure of PSA production/secretion and may prove to be a viable alternative/addition to current PSA assays Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, SDS-PAGE, pro-PSA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by centrifugation and gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
urine activation peptide of PSA is filtered from the bloodstream by the kidney, and is detectable in the urine of patients with prostate cancer, but not controls. Serum PSA concentration is dependent on how much PSA gains access to the bloodstream and how efficiently it is removed Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 36000, SDS-PAGE, pro-PSA Homo sapiens

Synonyms

Synonyms Comment Organism
prostate-specific antigen
-
 Homo sapiens
PSA
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PSA is secreted as an inactive pro-enzyme containing an N-terminal seven amino acid (Ala-Pro-Leu-Ile-Leu-Ser-Arg) activation peptide, which is removed extracellularly in vivo Homo sapiens