Activating Compound | Comment | Organism | Structure |
---|---|---|---|
androgens | upregulation | Homo sapiens | |
progestins | upregulation in breast cancer | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | enzyme is a marker for cancer | Homo sapiens |
medicine | used in the diagnosis of prostate cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene hK3 or KLK3, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
insulin-like growth factor binding protein-3 + H2O | Homo sapiens | - |
insulin-like growth factor I + ? | i.e. IGF-I | ? | |
additional information | Homo sapiens | enzyme is regulated by steroid hormones, it contains 2 androgen-response elements in the proximal PSA promotor | ? | - |
? | |
additional information | Homo sapiens | stimulates cell detachment and facilitates tumor spread | ? | - |
? | |
plasminogen + H2O | Homo sapiens | - |
plasmin + ? | - |
? | |
polypeptide + H2O | Homo sapiens | enzyme possibly is involved in the processing of insulin-like growth factor binding protein 3 | peptides | - |
? | |
proform of transforming growth factor-beta + H2O | Homo sapiens | - |
transforming growth factor-beta + ? | i.e. IGF-beta | ? | |
semenogelin + H2O | Homo sapiens | - |
semenogelin fractions | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07288 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | enzyme can be activated by recombinant kallikrein 2 | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Preferential cleavage: -Tyr-/- | enzyme is a serine protease | Homo sapiens | |
Preferential cleavage: -Tyr-/- | enzyme contains a serine residue in the substrate binding pocket | Homo sapiens | |
Preferential cleavage: -Tyr-/- | enzyme shows chymotrypsin-like activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | female | Homo sapiens | - |
breast carcinoma cell | - |
Homo sapiens | - |
BT-474 cell | breast carcinoma cell line, enzyme is upregulated by progestins and androgens | Homo sapiens | - |
lung | - |
Homo sapiens | - |
prostate | highest expression level | Homo sapiens | - |
prostate cancer cell | upregulation of gene expression by androgens | Homo sapiens | - |
prostate cancer cell | metastatic prostate adenocarcinoma cell line LNCaP | Homo sapiens | - |
salivary gland | - |
Homo sapiens | - |
seminal plasma | - |
Homo sapiens | - |
T47-D cell | breast carcinoma cell line, enzyme is upregulated by progestins and androgens | Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
trachea | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
insulin-like growth factor binding protein-3 + H2O | - |
Homo sapiens | insulin-like growth factor I + ? | i.e. IGF-I | ? | |
additional information | enzyme is regulated by steroid hormones, it contains 2 androgen-response elements in the proximal PSA promotor | Homo sapiens | ? | - |
? | |
additional information | stimulates cell detachment and facilitates tumor spread | Homo sapiens | ? | - |
? | |
plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
polypeptide + H2O | enzyme possibly is involved in the processing of insulin-like growth factor binding protein 3 | Homo sapiens | peptides | - |
? | |
proform of transforming growth factor-beta + H2O | - |
Homo sapiens | transforming growth factor-beta + ? | i.e. IGF-beta | ? | |
semenogelin + H2O | semenogelins I and II | Homo sapiens | semenogelin fragments | - |
? | |
semenogelin + H2O | - |
Homo sapiens | semenogelin fractions | - |
? |
Synonyms | Comment | Organism |
---|---|---|
K3 | - |
Homo sapiens |
prostate-specific antigen | - |
Homo sapiens |