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Literature summary for 3.4.21.77 extracted from

  • Yousef, G.M.; Diamandis, E.P.
    The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
androgens upregulation Homo sapiens
progestins upregulation in breast cancer Homo sapiens

Application

Application Comment Organism
medicine enzyme is a marker for cancer Homo sapiens
medicine used in the diagnosis of prostate cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene hK3 or KLK3, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibronectin + H2O Homo sapiens
-
?
-
?
insulin-like growth factor binding protein-3 + H2O Homo sapiens
-
insulin-like growth factor I + ? i.e. IGF-I ?
additional information Homo sapiens enzyme is regulated by steroid hormones, it contains 2 androgen-response elements in the proximal PSA promotor ?
-
?
additional information Homo sapiens stimulates cell detachment and facilitates tumor spread ?
-
?
plasminogen + H2O Homo sapiens
-
plasmin + ?
-
?
polypeptide + H2O Homo sapiens enzyme possibly is involved in the processing of insulin-like growth factor binding protein 3 peptides
-
?
proform of transforming growth factor-beta + H2O Homo sapiens
-
transforming growth factor-beta + ? i.e. IGF-beta ?
semenogelin + H2O Homo sapiens
-
semenogelin fractions
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07288
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme can be activated by recombinant kallikrein 2 Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
Preferential cleavage: -Tyr-/- enzyme is a serine protease Homo sapiens
Preferential cleavage: -Tyr-/- enzyme contains a serine residue in the substrate binding pocket Homo sapiens
Preferential cleavage: -Tyr-/- enzyme shows chymotrypsin-like activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast female Homo sapiens
-
breast carcinoma cell
-
Homo sapiens
-
BT-474 cell breast carcinoma cell line, enzyme is upregulated by progestins and androgens Homo sapiens
-
lung
-
Homo sapiens
-
prostate highest expression level Homo sapiens
-
prostate cancer cell upregulation of gene expression by androgens Homo sapiens
-
prostate cancer cell metastatic prostate adenocarcinoma cell line LNCaP Homo sapiens
-
salivary gland
-
Homo sapiens
-
seminal plasma
-
Homo sapiens
-
T47-D cell breast carcinoma cell line, enzyme is upregulated by progestins and androgens Homo sapiens
-
thyroid gland
-
Homo sapiens
-
trachea
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
Homo sapiens ?
-
?
insulin-like growth factor binding protein-3 + H2O
-
Homo sapiens insulin-like growth factor I + ? i.e. IGF-I ?
additional information enzyme is regulated by steroid hormones, it contains 2 androgen-response elements in the proximal PSA promotor Homo sapiens ?
-
?
additional information stimulates cell detachment and facilitates tumor spread Homo sapiens ?
-
?
plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?
polypeptide + H2O
-
Homo sapiens peptides
-
?
polypeptide + H2O enzyme possibly is involved in the processing of insulin-like growth factor binding protein 3 Homo sapiens peptides
-
?
proform of transforming growth factor-beta + H2O
-
Homo sapiens transforming growth factor-beta + ? i.e. IGF-beta ?
semenogelin + H2O semenogelins I and II Homo sapiens semenogelin fragments
-
?
semenogelin + H2O
-
Homo sapiens semenogelin fractions
-
?

Synonyms

Synonyms Comment Organism
K3
-
Homo sapiens
prostate-specific antigen
-
Homo sapiens