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Literature summary for 3.4.21.76 extracted from

  • Joosten, L.A.; Netea, M.G.; Fantuzzi, G.; Koenders, M.I.; Helsen, M.M.; Sparrer, H.; Pham, C.T.; van der Meer, J.W.; Dinarello, C.A.; van den Berg, W.B.
    Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta (2009), Arthritis Rheum., 60, 3651-3662.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine only therapies based on the dual inhibition of caspase 1 and serine proteases will be successful in the management of complex inflammatory diseases in humans Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
male C57BL/6 and BALB/c mice
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proIL-1beta + H2O is processed by PR3 or caspase 1 Homo sapiens active IL-1beta + ?
-
?

Synonyms

Synonyms Comment Organism
PR3
-
Mus musculus
PR3
-
Homo sapiens
proteinase 3
-
Mus musculus
proteinase 3
-
Homo sapiens

General Information

General Information Comment Organism
malfunction in mice lacking neutrophil serine PR3 (DPPI-/- mice), inhibition of caspase 1 activity results in decreased bioactive IL-1beta concentrations in the synovial tissue and less suppression of chondrocyte anabolic function. Dual blockade of both PR3 and caspase 1 leads to protection against cartilage and bone destruction. Deficiency of PR3 in combination with inhibition of caspase 1 does not reduce the joint swelling in streptococcal cell wall-induced acute arthritis Mus musculus
physiological function activation of IL-1beta in a manner independent of caspase 1 is especially apparent in the acute phase of inflammation, characterized by a predominantly neutrophilic infiltrate that serves as a source for PR3 Homo sapiens
physiological function caspase 1-independent processing of IL-1beta occurs in arthritis by serine proteases such as PR3 Mus musculus