Application | Comment | Organism |
---|---|---|
medicine | only therapies based on the dual inhibition of caspase 1 and serine proteases will be successful in the management of complex inflammatory diseases in humans | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male C57BL/6 and BALB/c mice | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proIL-1beta + H2O | is processed by PR3 or caspase 1 | Homo sapiens | active IL-1beta + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PR3 | - |
Mus musculus |
PR3 | - |
Homo sapiens |
proteinase 3 | - |
Mus musculus |
proteinase 3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | in mice lacking neutrophil serine PR3 (DPPI-/- mice), inhibition of caspase 1 activity results in decreased bioactive IL-1beta concentrations in the synovial tissue and less suppression of chondrocyte anabolic function. Dual blockade of both PR3 and caspase 1 leads to protection against cartilage and bone destruction. Deficiency of PR3 in combination with inhibition of caspase 1 does not reduce the joint swelling in streptococcal cell wall-induced acute arthritis | Mus musculus |
physiological function | activation of IL-1beta in a manner independent of caspase 1 is especially apparent in the acute phase of inflammation, characterized by a predominantly neutrophilic infiltrate that serves as a source for PR3 | Homo sapiens |
physiological function | caspase 1-independent processing of IL-1beta occurs in arthritis by serine proteases such as PR3 | Mus musculus |