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Literature summary for 3.4.21.76 extracted from

  • Csernok, E.; Moosig, F.; Gross, W.L.
    Pathways to ANCA production: From differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegeners granuloma (2008), Clin. Rev. Allergy Immunol., 34, 300-306.
    View publication on PubMed
Search for more literature for 3.4.21.76

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha leads to caspase-3-dependent apoptosis within 3 h accompanied by increased surface expression of PR3 and MPO Homo sapiens

Application

Application Comment Organism
medicine PR3 induces DC maturation via protease-activated receptor-2. Wegener’s autoantigen PR3 interacts with a “gateway” receptor (protease-activated receptor-2) on iDCs in vitro, triggering their maturation and licenses them for a Th1-type response potentially favoring granuloma formation in Wegener’s granulomatosis. PR3-anti-neutrophil cytoplasmic antibodies are strongly associated with Wegener’s granulomatosis. PR3-anti-neutrophil cytoplasmic antibodies opsonization of apoptotic neutrophils results in effective phagocytosis by human monocyte-derived macrophages and leads to up-regulation of proinflammatory mediator production. An animal model for PR3-anti-neutrophil cytoplasmic antibodies-associated vasculitis that shows characteristics similar to human Wegener’s granulomatosis is not yet available Homo sapiens
medicine PR3-anti-neutrophil cytoplasmic antibodies from Wegener’s granulomatosis patients do not recognize the natively folded murine PR3 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PR3 induces phenotypic and functional maturation of blood monocyte-derived iDCs Homo sapiens ?
-
 ?
protease-activated receptor-2 PR3 may possess the capacity to interact and activate protease-activated receptor-2 expressing antigen-presenting cells and thereby potentially link this proinflammatory activity to the initiation of an adaptive immune response (induction of PR3-specific T cells) Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PR3
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 Mus musculus
PR3
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 Homo sapiens
proteinase 3
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 Mus musculus
proteinase 3
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 Homo sapiens