Literature summary for 3.4.21.76 extracted from

Kantari, C.; Pederzoli-Ribeil, M.; Amir-Moazami, O.; Gausson-Dorey, V.; Moura, I.C.; Lecomte, M.C.; Benhamou, M.; Witko-Sarsat, V.
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis (2007), Blood, 110, 4086-4095.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	PR3 externalization depends on PLSCR1, but is independently of its serine-proteinase activity. Higher membrane PR3 expression on neutrophils after apoptosis without degranulation. Phospholipid scramblase 1 is involved in membrane PR3 expression during apoptosis-induced phospholipid redistribution between the two plasma membrane leaflets	Homo sapiens

Application

Application	Comment	Organism
medicine	proinflammatory role of membrane PR3 expression may involve interference with macrophage clearance of apoptotic neutrophils	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
RBL-2H3 rat mast-cell line stably transfected with PR3 or its inactive mutant S203A	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
S203A	enzymatically inactive. PR3 externalization depends on PLSCR1, but is independently of its serine-proteinase activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
siRNA	less PR3 externalization in the presence of rPLSCR1 siRNA	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Homo sapiens	9986	-
cytoplasm	PR3-phospholipid scramblase 1 colocolization	Homo sapiens	5737	-
plasma membrane	PR3-phospholipid scramblase 1 colocolization	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	PR3-phospholipid scramblase 1 interaction	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PR3	-	Homo sapiens
proteinase 3	-	Homo sapiens
Wegener autoantigen	-	Homo sapiens

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Release 2023.1 (January 2023)