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Literature summary for 3.4.21.76 extracted from

  • Mueller, A.; Voswinkel, J.; Gottschlich, S.; Csernok, E.
    Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses (2007), Ann. N. Y. Acad. Sci., 1109, 84-92.
    View publication on PubMed
Search for more literature for 3.4.21.76

Application

Application Comment Organism
medicine involved in autoimmune small vessel vasculitides, e. g. Wegener´s granulomatosis. PR3 is the main target autoatigen of antineutrophilic cytoplasmic antibodies (ANCA). Structure(charge)-based binding interactions between PR3-ANCA and conformational epitopes of PR3. Binding of PR3 to physiological molecules as well as to autoantibodies may induce and promote proinflammatory responses Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin physiologic inhibitor of PR3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
azurophil granule
-
 Homo sapiens 42582
-
cell surface
-
 Homo sapiens 9986
-
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
polymorphonuclear leukocyte
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IL-32 + H2O
-
 Homo sapiens ?
-
 ?
protease-activated receptor-2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PR3
-
 Homo sapiens
proteinase 3
-
 Homo sapiens