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Literature summary for 3.4.21.76 extracted from

  • Koehl, C.; Knight, C.G.; Bieth, J.G.
    Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts (2003), J. Biol. Chem., 278, 12609-12612.
    View publication on PubMed
Search for more literature for 3.4.21.76

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.1
-
 MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.14
-
 MeOSuc-Lys(2-picolinoyl)-Ala-Pro-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.17
-
 Suc-Ala-Tyr-Leu-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.38
-
 Suc-Ala-Ala-Pro-2-aminobutyric acid-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.47
-
 MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.5
-
 Suc-Ala-Ala-Pro-Nva-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.6
-
 Suc-Ala-Ala-Pro-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.62
-
 Suc-Ala-Ala-Asp-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.64
-
 Suc-Ala-Ala-Pro-Ile-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.9
-
 Suc-Leu-Val-Glu-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
0.97
-
 Suc-Ala-Ala-Glu-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
1.9
-
 Suc-Ala-Ala-Pro-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
2
-
 Boc-Ala-Ala-Pro-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
2.7
-
 Ac-Ala-Ala-Pro-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
2.8
-
 Ac-Ala-Ala-Pro-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Ala-Ala-Ala-Ala-Lys-Gly-Asp-Dpa-NH2 + H2O
-
 Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Ala-Ala-Pro-Leu-Lys-Gly-Asp-Dpa-NH2 + H2O
-
 Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Ala-Ala-Pro-Val-Lys-Gly-Asp-Dpa-NH2 + H2O
-
 Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Lys(2-picolinoyl)-Tyr-Asp-Ala-Lys-Gly-Asp-Dpa-NH2 + H2O
-
 Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Lys(2-picolinoyl)-Tyr-Asp-Ile-Lys-Gly-Asp-Dpa-NH2 + H2O
-
 Homo sapiens ?
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Lys(2-picolinoyl)-Val-Glu-Ala-Lys-Gly-Asp-Dpa-NH2 + H2O
-
 Homo sapiens ?
-
 ?
Ac-Ala-Ala-Pro-Ala-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Ac-Ala-Ala-Pro-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Boc-Ala-Ala-Pro-Ala-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
MeOSuc-Lys(2-picolinoyl)-Ala-Pro-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Ala-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
additional information Suc-Ala-Ala-Ala-Ala-p-nitroanilide, Suc-Ala-Ala-Pro-Met-p-nitroanilide, Suc-Ala-Ala-Pro-Leu, and Suc-Ala-Ala-Pro-Nle-p-nitroanilide -p-nitroanilide are no substrates Homo sapiens ?
-
 ?
Suc-Ala-Ala-Asp-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Ala-Glu-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Ala-Pro-2-aminobutyric acid-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Ala-Pro-Ala-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Ala-Pro-Ile-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Ala-Pro-Nva-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Ala-Pro-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala-Tyr-Leu-Val-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Ala4-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
Suc-Leu-Val-Glu-Ala-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil proteinase 3
-
 Homo sapiens
proteinase 3
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2 8 Suc-Leu-Val-Glu-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
3 6 Suc-Ala-Tyr-Leu-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
5.4
-
 Suc-Ala-Ala-Pro-Nva-p-nitroanilide pH 7.4, 25°C Homo sapiens
12
-
 Suc-Ala-Ala-Pro-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
13.2
-
 Ac-Ala-Ala-Pro-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
13.8
-
 Suc-Ala-Ala-Pro-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
16.2
-
 Suc-Ala-Ala-Pro-Ile-p-nitroanilide pH 7.4, 25°C Homo sapiens
18
-
 Boc-Ala-Ala-Pro-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
22.2
-
 Suc-Leu-Val-Glu-Ala-p-nitroanilide pH 7.4, 25°C Homo sapiens
30
-
 Suc-Ala-Ala-Pro-2-aminobutyric acid-p-nitroanilide pH 7.4, 25°C Homo sapiens
30
-
 MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide pH 7.4,25°C Homo sapiens
60
-
 Suc-Ala-Ala-Glu-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
60
-
 Ac-Ala-Ala-Pro-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
84
-
 Suc-Ala-Ala-Asp-Val-p-nitroanilide pH 7.4, 25°C Homo sapiens
138
-
 MeOSuc-Lys(2-picolinoyl)-Ala-Pro-Val-p-nitroanilide H 7.4, 25°C Homo sapiens
192
-
 MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Ala-p-nitroanilide H 7.4, 25°C Homo sapiens
660
-
 MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Val-p-nitroanilide H 7.4, 25°C Homo sapiens