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Literature summary for 3.4.21.76 extracted from

  • Witko-Sarsat, V.; Canteloup, S.; Durant, S.; Desdouets, C.; Chabernaud, R.; Lemarchand, P.; Descamps-Latscha, B.
    Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation (2002), J. Biol. Chem., 277, 47338-47347.
    View publication on PubMed
Search for more literature for 3.4.21.76

Cloned(Commentary)

Cloned (Comment) Organism
recombinant PR3 expressed in HMC1 cells Homo sapiens
recombinant PR3 expressed in RBL cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone
-
 Homo sapiens
benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone
-
 Rattus norvegicus
lactacystin
-
 Homo sapiens
lactacystin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasmic vesicle
-
 Rattus norvegicus 31410
-
cytosol
-
 Rattus norvegicus 5829
-
membrane plasma membrane Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
 rat
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Ala-Pro-Nva-SBzl + H2O
-
 Homo sapiens ?
-
 ?
additional information PR3 induced cell proliferation is dependent on its serine proteinase activity Homo sapiens ?
-
 ?
p21 protein + H2O
-
 Homo sapiens ?
-
 ?
p21 protein + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
PR3
-
 Homo sapiens
Proteinase-3
-
 Homo sapiens