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Literature summary for 3.4.21.75 extracted from

  • Tse, L.V.; Hamilton, A.M.; Friling, T.; Whittaker, G.R.
    A novel activation mechanism of avian influenza virus H9N2 by furin (2014), J. Virol., 88, 1673-1683.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activation mechanism of avian influenza virus H9N2 by furin, overview. Israel810 HA can be cleaved in cells with high levels of furin expression, a mutation that eliminates a glycosylation site in HA1 allows the Israel810 hemagglutinin to gain universal cleavage in cell culture. Influenza virus HA is a complex protein, folded in a tertiary structure. In this situation, accessibility of the cleavage site to proteases becomes as important as the primary sequence itself ?
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Organism

Organism UniProt Comment Textmining
Gallus gallus
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Homo sapiens P09958
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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Homo sapiens
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additional information ubiquitous expression, although furin is expressed universally, expression levels vary and can be quite low depending on tissue types Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
avian influenza virus A hemagglutinin + H2O from strain vian influenza virus, A/chicken/Israel/810/2001 (H9N2), with R-S-K-R cleavage site Gallus gallus ?
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avian influenza virus A hemagglutinin + H2O from strain vian influenza virus, A/chicken/Israel/810/2001 (H9N2), with R-S-K-R cleavage site Homo sapiens ?
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additional information activation mechanism of avian influenza virus H9N2 by furin, overview. Israel810 HA can be cleaved in cells with high levels of furin expression, a mutation that eliminates a glycosylation site in HA1 allows the Israel810 hemagglutinin to gain universal cleavage in cell culture. Influenza virus HA is a complex protein, folded in a tertiary structure. In this situation, accessibility of the cleavage site to proteases becomes as important as the primary sequence itself Homo sapiens ?
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?

General Information

General Information Comment Organism
evolution furin is a member of the proprotein convertase family Gallus gallus
evolution furin is a member of the proprotein convertase family Homo sapiens
physiological function the furin expression level is directly proportional to the efficiency of hemagglutinin cleavage, with implications for viral spread in the host, activation mechanism of avian influenza virus H9N2 by furin, overview Homo sapiens