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Literature summary for 3.4.21.75 extracted from

  • Tafesse, F.G.; Guimaraes, C.P.; Maruyama, T.; Carette, J.E.; Lory, S.; Brummelkamp, T.R.; Ploegh, H.L.
    GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin (2014), J. Biol. Chem., 289, 24005-24018.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
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 Homo sapiens 5768
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additional information furin is a protease localized in the trans-Golgi network and in late endocytic compartments Homo sapiens
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trans-Golgi network
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 Homo sapiens 5802
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
G-protein-coupled receptor GPR107 + H2O Homo sapiens cleavage by endoprotease furin, a disulfide bond connects the two resulting fragments, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09958
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-

Source Tissue

Source Tissue Comment Organism Textmining
KBM-7 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
G-protein-coupled receptor GPR107 + H2O cleavage by endoprotease furin, a disulfide bond connects the two resulting fragments, overview Homo sapiens ?
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 ?
G-protein-coupled receptor GPR107 + H2O recombinant HA-tagged substrate expressed in HeLa cells. GPR107 contains an extended furin recognition site that includes KSKR, a variant of the classical furin cleavage motif (Arg-Xaa-(Lys/Arg)-Arg), although not common among furin substrates, in GPR107 the Lys residue replaces the first conserved Arg Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function furin is the major processing protease of the secretory pathway. GPR107 localizes to the trans-Golgi network and is essential for retrograde transport. It is cleaved by the endoprotease furin Homo sapiens